DBCO Phosphoramidite is a phosphoramidite reagent containing a dibenzocyclooctyne ( DBCO ) moiety, which can introduce a strain-promoted alkyne group for copper-free click chemistry into DNA strands during solid-phase oligonucleotide synthesis. DBCO Phosphoramidite is applicable to studies related to oligonucleotide modification, copper-free click conjugation, and functionalized DNA nanomaterials [1].
In Vitro, DBCO Phosphoramidite (0.1 M; 8-10 minutes) enables successful synthesis of folate-modified DNA strands via solid-phase synthesis, as verified by LC-MS analysis[1].
References:
[1]. Brown TM, et al. UV-Cross-Linked DNA Nanomaterials Enable Robust Nanopatterning of Folate Ligands for Enhanced Cellular Uptake. Journal of the American Chemical Society. 2025 Jun 04;147(22):18876-18887.
In Vitro, DBCO Phosphoramidite (0.1 M; 8-10 minutes) enables successful synthesis of folate-modified DNA strands via solid-phase synthesis, as verified by LC-MS analysis[1].
References:
[1]. Brown TM, et al. UV-Cross-Linked DNA Nanomaterials Enable Robust Nanopatterning of Folate Ligands for Enhanced Cellular Uptake. Journal of the American Chemical Society. 2025 Jun 04;147(22):18876-18887.