DG 041 |
| Catalog No.GC50393 |
DG 041은 결합 및 FLIPR 분석에서 각각 4.6nM 및 8.1nM의 IC50을 갖는 강력하고 고친화성 및 선택적 EP3 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 861238-35-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.
Markovič et al (2017) Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 22 57 PMID:27506873 |Singh et al (2009) Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 4 115 PMID:19193156
| Cas No. | 861238-35-9 | SDF | |
| Canonical SMILES | CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl | ||
| Formula | C23H15Cl4FN2O3S2 | M.Wt | 592.32 |
| Solubility | DMSO : 250 mg/mL (422.07 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.6883 mL | 8.4414 mL | 16.8828 mL |
| 5 mM | 337.7 μL | 1.6883 mL | 3.3766 mL |
| 10 mM | 168.8 μL | 844.1 μL | 1.6883 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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