Dichlorophenyl-ABA |
| Catalog No.GC38770 |
Dichlorophenyl-ABA는 TTR(transthyretin) 아밀로이드 원섬유 형성의 억제제로 TTR L55P 발현 세포에서 응집체 형성을 80% 이상 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 18201-65-5
Sample solution is provided at 25 µL, 10mM.
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Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1]. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].
[1]. Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408(1):131-8.
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