DKM 2-93 |
| Catalog No.GC32814 |
DKM 2-93은 430μM의 IC50을 갖는 UBA5의 비교적 선택적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65836-72-8
Sample solution is provided at 25 µL, 10mM.
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DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively[1].
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity[1].
[1]. Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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