GLPBio

DPP-4

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Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

Products Related to DPP-4(18)

  • GC12895 structure
    GC12895Saxagliptin
    CAS: 361442-04-8
    Purity: >99.50%

    Saxagliptin은 고효력의 디펩티딜 펩티다제-4(DPP-4) 억제제로 DPP-4 효소를 선택적으로 억제해서 내인성 글루카곤 유사 펩타이드-1(GLP-1) 및 포도당 의존성 인슐린 분비 촉진 폴리펩타이드(GIP) 수준을 상승시켜 혈당을 조절한다.

  • GC10104 structure
    GC10104Glimepiride
    CAS: 93479-97-1
    Purity: >98.00%

    Glimepiride는 췌장 β세포를 자극해서 인슐린을 방출하는 제2세대 설포닐류 약물이다. Glimepiride는 단독요법뿐만 아니라 메트포르민 또는 인슐린과의 병용요법으로 제2형 당뇨병을 치료하기 위해 사용된다.

  • GC10298 structure
    GC10298Sitagliptin phosphate monohydrate
    CAS: 654671-77-9
    Purity: >99.50%
  • GC10802 structure
    GC10802K 579
    CAS: 440100-64-1
    Purity: >98%
  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    Purity: >98.00%

    시타글립틴(인산염)(MK-0431 인산염)은 Caco-2 세포 추출물에서 IC50이 19nM인 DPP4의 강력한 억제제입니다.

  • GC12603 structure
    GC12603DPPI 1c hydrochloride
    CAS: 866396-34-1
    Purity: >98%

    A DPP-4 inhibitor

  • GC13949 structure
    GC13949Alogliptin Benzoate
    CAS: 850649-62-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC14126 structure
    GC14126NVP DPP 728 dihydrochloride
    CAS: 247016-69-9
    Purity: >98%
  • GC14201 structure
    GC14201PK 44 phosphate
    CAS: 1017682-65-3
    Purity: >98%

    DPP-IV inhibitor

  • GC14786 structure
    GC14786P32/98 (hemifumarate)
    CAS: 251572-86-8
    Purity: >98%

    P32/98(헤미푸마레이트)은 130nM의 Ki 값을 갖는 디펩티딜 펩티다제 IV의 강력한 억제제입니다.

  • GC14827 structure
    GC14827Linagliptin (BI-1356)
    CAS: 668270-12-0
    Purity: >99.50%

    A potent DPP-4 inhibitor

  • GC15130 structure
    GC15130Alogliptin (SYR-322)
    CAS: 850649-61-5
    Purity: >99.00%
  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC16613 structure
    GC16613Trelagliptin
    CAS: 865759-25-7
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC16733 structure
    GC16733Vildagliptin (LAF-237)
    CAS: 274901-16-5
    Purity: >98.00%

    A DPP-4 inhibitor

  • GC17012 structure
    GC17012MK3102
    CAS: 1226781-44-7
    Purity: >99.00%

    MK3102 (Omarigliptin)은 2형 다이아벳를 치료하기 위해 개발된 새로운 주 1회 복용용 이소화 펩타이드효소-4 (DPP-4) 억제제 (IC50: 2.2 nM)이다.

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC10018 structure
    GC10018Talabostat mesylate
    CAS: 150080-09-4
    Purity: >99.00%

    Talabostat mesylate은 구강 투여가능한 비선택성 이소펩타이드아제 IV（DPP-IV） 억제제（IC50 < 4 nM；Ki = 0.18 nM）로서 섬유 모세포 활성화 단백（FAP）의 첫 임상 억제제（IC50 = 560 nM）이다. 그것은 또한 DPP 8/9（IC50 = 4/11 nM；Ki = 1.5/0.76 nM）、프로린 내피펩티다아제（QPP）（IC50 = 310 nM）、DPP2그리고 기타 DASH 가족효소를 억제한다.