DSPE-PEG2000-Mal-Cys-penetratin is a conjugate composed of DSPE, a PEG chain, and terminal maleimide (Mal). DSPE-PEG2000-Mal-Cys-penetratin combines the membrane compatibility of lipids, the ability to undergo specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers ), and the ability to penetrate cell membranes, making it suitable for research on biomaterial construction and drug delivery to cells.
In Vitro, The structure of DSPE-PEG2000-Mal-Cys-penetratin comprises four key components, which work synergistically: DSPE: Acts as a hydrophobic anchor, responsible for securely embedding the entire molecule into the membrane structure of lipid nanoparticles. PEG chain: As a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo. Maleimide: Located at the end of the PEG chain, it acts as a reaction interface, undergoing specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) to achieve targeting or tracking functions. Cys-penetratin: Efficiently helps the entire nanoparticle cross the cell membrane and enter the cell to exert its effects.
In Vitro, The structure of DSPE-PEG2000-Mal-Cys-penetratin comprises four key components, which work synergistically: DSPE: Acts as a hydrophobic anchor, responsible for securely embedding the entire molecule into the membrane structure of lipid nanoparticles. PEG chain: As a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo. Maleimide: Located at the end of the PEG chain, it acts as a reaction interface, undergoing specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) to achieve targeting or tracking functions. Cys-penetratin: Efficiently helps the entire nanoparticle cross the cell membrane and enter the cell to exert its effects.