GLPBio

EZH2

EZH2 (enhancer of zeste homolog 2) is a polycomb group protein and histone methyltrasferase that associated with transcriptional repression. It catalyzes trimethylation of H3K27me3 (histone H3 lysine 27) as a catalytic subunit of PRC2 (polycomb repressive complex 2).

Products Related to EZH2(10)

  • GC11414 structure
    GC11414GSK503
    CAS: 1346572-63-1
    Purity: >99.50%

    GSK503은 3~27nM의 Kiapp 값을 갖는 EZH2 메틸트랜스퍼라제의 강력하고 특이적인 억제제입니다.

  • GC13145 structure
    GC131453-Deazaneplanocin,DZNep
    CAS: 102052-95-9
    Purity: >98.00%

    An inhibitor of lysine methyltransferase EZH2

  • GC13878 structure
    GC13878EPZ005687
    CAS: 1396772-26-1
    Purity: >99.00%

    A potent, selective inhibitor of EZH2

  • GC15783 structure
    GC15783GSK126
    CAS: 1346574-57-9
    Purity: >98.00%

    GSK126(GSK2816126A, GSK2816126)은 체외 실험(MM 세포)에서 IC50이 12.6-17.4nM이고 체내 실험(수컷 ApoE-/- 쥐)에서 IC50이 9.9nM인 매우 선택적인 EZH2 메틸 전이효소 억제제이다.

  • GC17534 structure
    GC17534GSK343
    CAS: 1346704-33-3
    Purity: >98.00%

    A selective, cell-permeable EZH2 inhibitor

  • GC17907 structure
    GC179073-Deazaneplanocin A (DZNep) hydrochloride
    CAS: 120964-45-6
    Purity: >99.50%

    3-Deazaneplanocin A (DZNep) hydrochloride는 아데노신 유사물이자 경쟁적인 S-아데노실호모시스테인 횡분해효소 억제제로서 세포 없는 실험에서 Ki 값이 50pM이다.

  • GC14756 structure
    GC14756EI1
    CAS: 1418308-27-6
    Purity: >99.50%

    EI1(KB-145943)은 EZH2(WT) 및 EZH2(Y641F)에 대해 IC50이 각각 15nM 및 13nM인 강력하고 선택적인 EZH2 억제제입니다.

  • GC11484 structure
    GC11484CPI-169 S-enantiomer
    Purity: >98%

    EZH2 inhibitor

  • GC12146 structure
    GC12146CPI-169 R-enantiomer
    CAS: 1802175-07-0
    Purity: >98%

    EZH2 inhibitor

  • GC16599 structure
    GC16599CPI-169
    CAS: 1450655-76-1
    Purity: >98.00%

    EZH2 inhibitor