Seltorexant (Synonyms: JNJ-42847922) |
| Catalog No.GC37623 |
셀토렉산트(JNJ-42847922)는 경구 활성, 고친화성 및 선택적 오렉신-2 수용체(OX2R) 길항제입니다(인간 및 쥐 OX2R의 경우 pKi 값 8.0 및 8.1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1293281-49-8
Sample solution is provided at 25 µL, 10mM.
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Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. pKi: 8.0 (human OX2R), 8.1 (rat OX2R)[1]
[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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