Stigmastanol은 자연형식의 포화된 식물성 스테롤이고 콜레스테롤과 유사한 화학 구조를 가진 식물성 스테롤류 화합물에 속한다. Stigmastanol은 콜레스테롤 흡수를 억제해서 혈중 지질을 낮출 수 있다[2]. Stigmastanol은 고콜레스테롤혈증을 예방하고 치료하는 기능성 식품에 자주 사용된다[3].
PC12 세포에서 Stigmastanol(1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h)은 D-갈락토스 유도 세포 사멸을 억제하였다[4].
Sprague-Dawley 쥐 모델에서 Stigmastanol(50mg/kg; 경구; 단회 투여)은 경구 투여 후 장내 콜레스테롤 흡수를 현저하게 억제하였다[5].
References:
[1]. Pinhas H, Loiseau A, Krikorian-Manoukian A, et al. 6-Amino derivatives of stigmastanol and cholestanol. Journal of Medicinal Chemistry. 1971 Nov; 14(11): 1048-1049.
[2]. Vahouny GV, Connor WE, Habiger RG, et al. Influence of stigmastanol and stigmastanyl-phosphorylcholine, two plasma cholesterol lowering substances, on synthetic phospholipid membranes. A 2H-and 31P-NMR study. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1992 Jan 10; 1103(1): 69-76.
[3]. Gupta E. β-Sitosterol: Predominant phytosterol of therapeutic potential. Innovations in food technology: current perspectives and future goals. 2020:465-477.
[4]. Zhang Y, Xu D, Zhang X, et al. Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation. Food Science and Human Wellness. 2025 Jul 1; 14(7).
[5]. Gershkovich P, Darlington J, Sivak O, et al. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. Journal of pharmaceutical sciences. 2009 Jul 1; 98(7): 2390-2400.