N6-Methyladenosine-5'-Triphosphate |
Catalog No.GN20007
One-Click Copy Product Info
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N6-Methyladenosine-5-Triphosphate (N6-methyl ATP; m6ATP)는 아데노신의 염기변형 수정 유사물로 자연 RNA에서 발견된 소량의 핵간산이다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N6-Methyladenosine-5-Triphosphate (N6-methyl ATP; m6ATP)는 아데노신의 염기변형 수정 유사물로 자연 RNA에서 발견된 소량의 핵간산이다. N6-Methyladenosine-5-Triphosphate는 역동적이고 되돌릴 수 있는 공유 수정된 뉴클레오티드로 진핵 생물의 메신저 RNA(mRNA)에서 일반적으로 발견되고 RNA 스플라이싱, 내보내기, 안정성 및 번역에서 중요한 규제 역할을 한다[2, 3]. N6-Methyladenosine-5-Triphosphate는 RNA 스플라이싱의 기제로 사용되고 mRNA 수정 반응에서 ATP의 완전한 대체재로 사용된다[4, 5]. 게다가 N6-Methyladenosine-5-Triphosphate는 기니피그와 대장균의 P2Y 퓨린성 수용체에 대한 효과적인 효능제이다[6]. 이 제품은 리튬 염액 형태로 제공된다.
References:
[1] Yuan Y, Arneson R, Burke E, et al. Efficient 3′-end tailing of RNA with modified adenosine for nanopore direct total RNA sequencing[J]. bioRxiv, 2024: 2024.02. 24.581884.
[2] Zheng H, Li S, Zhang X, et al. Functional implications of active N6-methyladenosine in plants[J]. Frontiers in Cell and Developmental Biology, 2020, 8: 291.
[3] Anderson S J, Kramer M C, Gosai S J, et al. N6-methyladenosine inhibits local ribonucleolytic cleavage to stabilize mRNAs in Arabidopsis[J]. Cell reports, 2018, 25(5): 1146-1157. e3.
[4] Parr C J C, Wada S, Kotake K, et al. N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells[J]. Nucleic Acids Research, 2020, 48(6): e35-e35.
[5] Potapov V, Fu X, Dai N, et al. Base modifications affecting RNA polymerase and reverse transcriptase fidelity[J]. Nucleic Acids Research, 2018, 46(11): 5753-5763.
[6] Burnstock G, Fischer B, Hoyle C H V, et al. Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes[J]. Drug development research, 1994, 31(3): 206-219.
| purity | >99.00% | Extinction Coefficient | 15,567 Lmol-1cm-1 at 265 nm |
| Formula | C11H18N5O13P3 (free acid) | M.Wt | 521.20 g/mole (free acid) |
| Salt Form | Li+ | Concentration | 100 mM |
| Buffer | H2O | Storage | -20°C or below |
| Synonyms | N6-Methyl-ATP, m6ATP | Backbone | 5'-Triphosphate |
| Base Analog | Adenosine | Sugar Type | RNA |
| Nucleotide Category | Base Modified RNA | ||
| Applications | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies | ||
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)