GLPBio

Iberiotoxin

Catalog No.: GC16254Purity:>98%
COASDSData Sheet
Iberiotoxin은 Buthus tamulus scorpion 독에서 분리된 독소입니다.

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

Iberiotoxin
Cas No.: 129203-60-7
100µgIn Stock
$417.00
1
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인용 문헌 (Citations)

현재 이 제품에 대한 인용 문헌이 없습니다. 아래는 GlpBio 제품을 인용한 주요 논문입니다.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

실험 프로토콜 (Protocol)

Cell experiment [1,2]:

Cell lines

Rat dorsal root ganglion neurons, bladder

Preparation method

Soluble to 0.70 mg/ml in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10-100 nM

Applications

Iberiotoxin (IbTX) (10-100 nM) increased the myogenic activity of bladder, but not portal vein. IbTX caused a sustained contracture of aorta. In rat dorsal root ganglion neurons, IbTx (100 nM) reduced whole-cell outward currents in 67% of small and medium size neurons. IbTx significantly prolonged the duration of action potential and increased firing frequency of afferent neurons.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Suarez-Kurtz, G. U. I. L. H. E. R. M. E., Garcia, M. L., & Kaczorowski, G. J. (1991). Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. Journal of Pharmacology and Experimental Therapeutics, 259(1), 439-443.

[2]. Zhang, X. F., Gopalakrishnan, M., & Shieh, C. C. (2003). Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons. Neuroscience, 122(4), 1003-1011.

화학적 특성 (Chemical Properties)

CAS 번호
129203-60-7
SMILES
CC(CC1/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N\C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\2)CCCNC(N)=N)CSSCC2/C(O)=N/C(/C(O)=N/C(C(O)=O)CCC(O)=N)CC3=CC=C(O)C=C3)CCCCN)CCCCN)CCSC)CSSCC(/N=C(O)/C(
분자식
C179H274N50O55S7
분자량
4230.85
용해도
H2O : ≥ 0.7 mg/mL (0.17 mM)
보관
Desiccate at -20°C
일반 주의사항
제품의 용해도 데이터에 따라 적절한 용매를 선택하십시오. 조제 후에는 반복적인 동결·해동을 피할 수 있도록 저장 용액을 소분하십시오.
저장 용액은 -80°C 보관 시 6개월 이내, -20°C 보관 시 1개월 이내에 사용하십시오.
용해도를 높이려면 튜브를 37°C로 데운 뒤 적절한 시간 동안 초음파 처리하십시오.
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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