KF-52 is a phosphofructokinase-1 ( PFK1 ) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction [1].
In Vitro, KF-52 (Compound 1c) inhibits purified phosphofructokinase-1 (PFK1) with an IC50 of 2.1 μM[1]. KF-52 (0-60 μM) increases the OCR/ECAR ratio in HeLa cells[1].
References:
[1]. Kakehi R, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024;16(1):59-63. Published 2024 Dec 4.
In Vitro, KF-52 (Compound 1c) inhibits purified phosphofructokinase-1 (PFK1) with an IC50 of 2.1 μM[1]. KF-52 (0-60 μM) increases the OCR/ECAR ratio in HeLa cells[1].
References:
[1]. Kakehi R, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024;16(1):59-63. Published 2024 Dec 4.