KISS1-305 is a peptide agonist of the kisspeptin receptor.1 It induces calcium mobilization in a reporter assay using CHO cells expressing the kisspeptin receptor (EC50 = 2.6 nM for the human receptor). KISS1-305 reduces plasma levels of testosterone below the limit of detection in male rats. It increases the number of ovulated oocytes in horse chorionic gonadotropin-stimulated immature female rats when administered at a dose of 100 nmol/kg.2
References:
[1]. Asami, T., Nishizawa, N., Matsui, H., et al.Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activityJ. Med. Chem.57(14)6105-6115(2014).
[2]. Asami, T., Nishizawa, N., Matsui, H., et al.Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activityJ. Med. Chem.56(21)8298-8307(2013).