KY-556 (N556) (Synonyms: N556) |
| Catalog No.GC31971 |
KY-556(N556)은 알레르기 질환에 대한 유망하고 경구 활성이 있는 DSCG(disodium cromoglycate) 전구약물입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110816-78-9
Sample solution is provided at 25 µL, 10mM.
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KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.
The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].
[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.
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