Mutanocyclin (8, 16, 32 µg/mL, 24, 36 h) inhibits Candida albicans (C. albicans) filamentation in a dose-dependent manner[1].
Mutanocyclin (32 µg/mL) decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1 in C. albicans cells[1].
Mutanocyclin functions by regulating the PKA catabolic subunit Tpk2 and its preferential binding target Sfl1[1].
Mutanocyclin (32 µg/mL; 24 h infects tongues of mouse) inhibits yeast-form in ex vivo mouse tongue infection models of C. albicans[1].
Mutanocyclin (6.4, 12.8, 25.6 µg/mL; 48 h) attenuates the virulence of C. albicans in the G. mellonella infection model[1].
References:
[1]. Tao L, et al. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid. Virulence. 2022 Dec;13(1):542-557.