PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM).1 This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.1 PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.2
References:
[1]. Glass, D.B.Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitorsBiochem. J.213(1)159-164(1983).
[2]. Wexler, E.M., Stanton, P.K., and Nawy, S.Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesteraseJ. Neurosci.18(7)2342-2349(1998).