GLPBio

PLX-3618

Catalog No.: GC27962Purity:>99.50%
COASDSData Sheet

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM. 

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

PLX-3618
Cas No.: 2851986-76-8
10mM (in 1mL DMSO)In Stock
$410.00
1
1mgIn Stock
$122.00
1
5mgIn Stock
$310.00
1
10mgIn Stock
$504.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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제품 설명 (Description)

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM. PLX-3618 promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ligase substrate receptor DCAF11. PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in acute myeloid leukemia (AML) cells. PLX-3618 can be used in studies related to acute myeloid leukemia (AML)[1].

References:

[1]. Parker GS, et al. Discovery of Monovalent Direct Degraders of BRD4 that Act via the Recruitment of DCAF11. Mol Cancer Ther. 2024;23(10):1446-1458.

제품 문서 (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

화학적 특성 (Chemical Properties)

CAS 번호
2851986-76-8
분자식
C32H27N9O2S
분자량
601.68
용해도
DMSO : 100 mg/mL (166.20 mM; Need ultrasonic)
보관
Store at -20°C
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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