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Poly(A) polymerase

Catalog No.GC81655 Copy One-Click Copy Product Info

Poly(A) polymerase catalyzes the incorporation of ATP into the RNA 3' end in the form of AMP, that is, adding a polyadenosine tail at the RNA 3' end.

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Poly(A) polymerase Chemical Structure

Cas No.: 9026-30-6

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100U
US$153.00
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Sample solution is provided at 25 µL, 10mM.



Description of Poly(A) polymerase

Poly(A) polymerase catalyzes the incorporation of ATP into the RNA 3' end in the form of AMP, that is, adding a polyadenosine tail at the RNA 3' end. Poly(A) polymerase increases RNA stability and increases mRNA translation efficiency in eukaryotic cells. Poly(A) polymerase has high tailing efficiency and can add 20-200 A bases to the 3' end of RNA [1] [2].

In Vitro, Table. Package Contents Specification Type Components Volume Quantity 100 U A Poly(A) Polymerase (5U/μL) 100 U 1 100 U B 10 x Poly(A) Polymerase Buffer 1 mL 1 100 U C ATP (10 mM) 0.1 mL 1

References:
[1]. Li W, et al. The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs. Adv Biol Regul. 2013 Jan;53(1):64-76.
[2]. Chen LS, et al. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol. 2010 Mar 1;79(5):669-77.

Chemical Properties of Poly(A) polymerase

Cas No. 9026-30-6 SDF
Formula M.Wt
Solubility Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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