PyAOP |
Catalog No.GA10267
One-Click Copy Product Info
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PyAOP는 펩타이드 합성에서 카르복실산과 아민을 아마이드로 전환하는 결합 시약이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 156311-83-0
Sample solution is provided at 25 µL, 10mM.
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PyAOP는 펩타이드 합성에서 카르복실산과 아민을 아마이드로 전환하는 결합 시약이다. PyAOP는 HOAt 계열의 아마이드 결합 형성 시약의 유도체로 구아니딘 형성의 위험 없이 아마이드 결합을 중재하고 펩타이드 환형화의 선호 시약이다[2, 3]. PyAOP는 고체상 펩타이드 합성을 통해 N, N′-치환된 아실구아니딘을 합성하고 반복 펩타이드 하이브리드 합성 중 펩타이드 결합 형성을 촉진할 수 있다[4, 5]. PyAOP는 HATU를 대체하고Arg과Phe의 결합을 완료할 수 있다[6].
References:
[1] Hu L, Zhao J. Ynamide: a new coupling reagent for amide and peptide synthesis[J]. Synlett, 2017, 28(14): 1663-1670.
[2] Albericio F, El-Faham A. Choosing the right coupling reagent for peptides: a twenty-five-year journey[J]. Organic Process Research & Development, 2018, 22(7): 760-772.
[3] Sarojini V, Cameron A J, Varnava K G, et al. Cyclic tetrapeptides from nature and design: A review of synthetic methodologies, structure, and function[J]. Chemical reviews, 2019, 119(17): 10318-10359.
[4] Dodd D S, Zhao Y. Solid-phase synthesis of N, N′-substituted acylguanidines[J]. Tetrahedron Letters, 2001, 42(7): 1259-1262.
[5] Planas M, Bardajı́ E, Barany G. Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains[J]. Tetrahedron Letters, 2000, 41(21): 4097-4100.
[6] Evans E D, Pentelute B L. Discovery of a 29-amino-acid reactive abiotic peptide for selective cysteine arylation[J]. ACS chemical biology, 2017, 13(3): 527-532.
| Cas No. | 156311-83-0 | SDF | |
| Chemical Name | tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium;hexafluorophosphate | ||
| Canonical SMILES | C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=C(C=CC=N5)N=N4.F[P-](F)(F)(F)(F)F | ||
| Formula | C17H27F6N7OP2 | M.Wt | 521.38 |
| Solubility | Soluble in water or 1% acetic acid | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.918 mL | 9.5899 mL | 19.1799 mL |
| 5 mM | 383.6 μL | 1.918 mL | 3.836 mL |
| 10 mM | 191.8 μL | 959 μL | 1.918 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)