Quorum sensing-IN-11 is a quorum sensining inhibitor and a LasR antagonist with an IC50 of 0.7399 μM. Quorum sensing-IN-11 inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa. Quorum sensing-IN-11 can be used for the research of Pseudomonas aeruginosa infection [1].
In Vitro, Quorum sensing-IN-11 (Compound 7f) (24 h) inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa by 83, 76, 90%[1]. Quorum sensing-IN-11 (0.1-10 μM; 4 h) potently inhibits LasR in the β-galactosidase reporter assay with an IC50 of 0.7399 ± 0.005 μM[1].
References:
[1]. Mohammed E Z, et al. Design, regioselective, time gated synthesis of novel benzo [d] imidazole analogues as potential quorum sensing inhibitors targeting LasR in Pseudomonas aeruginosa[J]. Bioorganic Chemistry, 2026: 109561.
In Vitro, Quorum sensing-IN-11 (Compound 7f) (24 h) inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa by 83, 76, 90%[1]. Quorum sensing-IN-11 (0.1-10 μM; 4 h) potently inhibits LasR in the β-galactosidase reporter assay with an IC50 of 0.7399 ± 0.005 μM[1].
References:
[1]. Mohammed E Z, et al. Design, regioselective, time gated synthesis of novel benzo [d] imidazole analogues as potential quorum sensing inhibitors targeting LasR in Pseudomonas aeruginosa[J]. Bioorganic Chemistry, 2026: 109561.