(R)-Liquiritigenin ((R)-4',7-Dihydroxyflavanone) is a MAO inhibitor that acts as an inhibitor of recombinant human MAO-A ( IC50 9.97 μM) and recombinant human MAO-B ( IC50 3.91 μM). (R)-Liquiritigenin is applicable to the research of neurodegenerative diseases [1].
In Vitro, (R)-Liquiritigenin (0.001-100 μM; 10 min pre-incubation, 20 min enzyme-substrate incubation) preferentially inhibits recombinant human MAO-B over MAO-A, with an IC50 of 3.91 μM for MAO-B and 9.97 μM for MAO-A[1].
References:
[1]. Mohamed EI, et al. Monoamine oxidases inhibitors from Colvillea racemosa: Isolation, biological evaluation, and computational study. Fitoterapia. 2018 Jan;124:217-223.
In Vitro, (R)-Liquiritigenin (0.001-100 μM; 10 min pre-incubation, 20 min enzyme-substrate incubation) preferentially inhibits recombinant human MAO-B over MAO-A, with an IC50 of 3.91 μM for MAO-B and 9.97 μM for MAO-A[1].
References:
[1]. Mohamed EI, et al. Monoamine oxidases inhibitors from Colvillea racemosa: Isolation, biological evaluation, and computational study. Fitoterapia. 2018 Jan;124:217-223.