KEAP1-Nrf2
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The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
Products Related to KEAP1-Nrf2(81)
- GN106295,7-dihydroxychromoneCAS: 31721-94-5Purity: >99.00%
5,7-dihydroxychromone은 땅콩 껍질에서 유래한 플라보노이드 분해 생성물로 벨벳잎, 옥수수, 땅콩 및 밀의 배아근 신장을 억제한다.
- GC16590Dimethyl FumarateCAS: 624-49-7Purity: >97.00%
Dimethyl fumarate(DMF)는 경구 활성 및 뇌 침투성 Nrf2 활성화제이며 항산화 유전자 발현의 상향 조절을 유도합니다.
- GC13693Omaveloxolone (RTA-408)CAS: 1474034-05-3Purity: >98.00%
Omaveloxolone (RTA-408)은 항산화 염증 조절제(AIM)로 Nrf2를 활성화하고 일산화질소(NO)를 억제한다.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GN10415 | Astilbin | 29838-67-3 | >97.00% | |
| GN10470 | Eriodictyol | 552-58-9 | >99.50% | |
| GN10491 | Mangiferin | 4773-96-0 | >99.50% | |
| GN10531 | Dimethylfraxetin | 6035-49-0 | >99.50% | |
| GN10629 | 5,7-dihydroxychromone | 31721-94-5 | >99.00% | |
5,7-dihydroxychromone은 땅콩 껍질에서 유래한 플라보노이드 분해 생성물로 벨벳잎, 옥수수, 땅콩 및 밀의 배아근 신장을 억제한다. | ||||
| GN10654 | (+)-Corynoline | 18797-79-0 | >98.00% | |
| GN10741 | Garcinone D | 107390-08-9 | >98.00% | |
| GC16590 | Dimethyl Fumarate | 624-49-7 | >97.00% | |
Dimethyl fumarate(DMF)는 경구 활성 및 뇌 침투성 Nrf2 활성화제이며 항산화 유전자 발현의 상향 조절을 유도합니다. | ||||
| GC13693 | Omaveloxolone (RTA-408) | 1474034-05-3 | >98.00% | |
Omaveloxolone (RTA-408)은 항산화 염증 조절제(AIM)로 Nrf2를 활성화하고 일산화질소(NO)를 억제한다. | ||||