Vasodilation

HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 μM, respectively).

Fasudil (HA-1077; AT877) 디 하이드로 클로라이드는 비특이적 rhoA/암석 억제제이며 또한 단백질 키나제에 대한 억제 효과가 있으며, 0.33 &7##8886; m 0.158&777###956; offlineefficient_models_2022q2.md;M, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.en_ko_2021q1.mdHA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.en_ko_2021q1.md

L-hydroxy Arginine is a substrate for nitric oxide synthase in the catabolism of L-arginine to form nitric oxide.

Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.

N-Desmethyl sildenafil is a major metabolite of sildenafil.

Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

Neurokinin A is a peptide agonist of the neurokinin-2 (NK2) receptor.

Neurokinin B is a tachykinin peptide agonist of the neurokinin-3 receptor (NK3; Ki = 0.8 nM).

Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin that binds to rat synaptic membranes with a Ki value of 13 nM.

Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.

Pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is a PACAP receptor agonist with IC50 values of 4, 2, and 1 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.

PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2.

PAR4 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence.

Phenylephrine glucuronide is a metabolite of the α1A-adrenergic receptor agonist phenylephrine .

Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).

Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM).

Vasoactive intestinal peptide (VIP) is a peptide that acts as a neurotransmitter and hormone.

α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.

Flupirtine-d4(D 9998-d4) 염산염은 Flupirtine이라고 표시된 중수소입니다.

A PDE3 inhibitor