Dihydrolycorine |
| Catalog No.GC45427 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6271-21-2
Sample solution is provided at 25 µL, 10mM.
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Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities.1 It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.2
References
1. Chen, B.Y., Du, Z.H., Zeng, F.D., et al. Hypotensive effect of dihydrolycorine. Zhongguo Yao Li Xue Bao 14(1), 45-49 (1993).
2. Jiang, S., Yu, G., Yu, L., et al. Therapeutic effect of dihydrolycorine on focal cerebral ischemia-reperfusion injury in rats. Yunyang Yixueyuan Xuebao 28(5), 453-456 (2009).
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