Behavioral Neuroscience

Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone.

A histamine H 3 receptor antagonist

Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors.

Metaraminol is a vasoconstrictor.

Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.

Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).

Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).

Norfluoxetine (hydrochloride)은 간에서 N-디메틸화를 통해 생성되는 플루옥세틴의 활성 대사물질로 경구 활성을 가진다.

Olanzapine thiolactam impurity is a potential impurity found in commercial preparations of olanzapine.

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.

Oxyntomodulin is a peptide hormone involved in regulation of food intake, energy expenditure, and glucose metabolism.

Pituitary adenylate cyclase-activating peptide (PACAP) (6-38) is a PACAP receptor antagonist with IC50 values of 30, 600, and 40 nM, respectively for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.

Peptide YY (human) (trifluoroacetate salt)은 장내 L 세포에서 분비되는 펩타이드 호르몬이다.

PQ-10은 각각 4.6nM 및 13mg/kg의 IC50 및 ED50을 갖는 포스포디에스테라제 10A(PDE10A)의 강력한 억제제입니다.

Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.

Pyrithiamine (hydrobromide)은 티아민(비타민 B1)의 신진대사를 억제하는 티아민 유사물질이다.

Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).

Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM).

TTK21은 히스톤 아세틸트랜스퍼라제 CBP/p300의 활성화제입니다.

Uridine-3'-monophosphate is a nucleoside used in the biochemical synthesis of ribothymidine-3'-phosphate.

Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).

Vasoactive intestinal peptide (VIP) is a peptide that acts as a neurotransmitter and hormone.

Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene.