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GPR139

GPR139 (G protein-coupled receptor 139) is a protein that in humans is encoded by the GPR139 gene. GPR139 is an orphan G-protein–coupled receptor expressed in the central nervous system.

The expression pattern of GPR139 has primarily been studied on the mRNA level and showed expression mainly in the central nervous system.

GPR139 is an orphan receptor identified from bioinformatics analysis of the human genome. GPR139 is thus a potential target for the treatment of Parkinson’s disease, obesity, eating disorders, and/or diabetes.

The GPR139 is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. GPR139 agonists dose-dependently protect primary dopaminergic (DA) neurons against MPP+ toxicity.

Targets for  GPR139

Products for  GPR139

  1. Cat.No. 상품명 정보
  2. GC19209 JNJ-63533054 JNJ-63533054는 인간 GPR139(hGPR139)에 대해 EC50이 16nM인 강력한 선택적 경구 활성 GPR139 작용제입니다. JNJ-63533054  Chemical Structure
  3. GC66431 NCRW0005-F05 NCRW0005-F05는 IC50 값이 0.21 μM인 강력한 GPR139 작용제입니다. 821d96072c2d58d8970e76f526b0f6b8NCRW0005-F05는 당뇨병, 비만 및 파킨슨병 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8 NCRW0005-F05  Chemical Structure

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