GLPBio

Serotonin Transporter

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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products Related to Serotonin Transporter(61)

  • GC60394 structure
    GC60394(±)-Duloxetine hydrochloride
    CAS: 947316-47-4
    Purity: >99.50%

    (±)-둘록세틴((Rac)-둘록세틴) 염산염은 둘록세틴 염산염의 라세미체입니다.

  • GC60424 structure
    GC60424(S)-Venlafaxine
    CAS: 93413-44-6
    Purity: >98%

    (S)-Venlafaxine은 Venlafaxine의 (S)-구성입니다. 벤라팍신은 경구 활성, 강력한 세로토닌(5-HT)/노르에피네프린(NE) 재흡수 이중 억제제입니다. 벤라팍신은 항우울제입니다.

  • GC60740 structure
    GC60740Dapoxetine-D7 hydrochloride
    CAS: 129938-20-1
    Purity: >99.50%

    Dapoxetine-d7(LY-210448-d7) 염산염은 Dapoxetine 염산염으로 표지된 중수소입니다.

  • GC65014 structure
    GC65014DSP-1053
    CAS: 1176326-76-3
    Purity: >99.00%

    벤질피페리딘 유도체인 DSP-1053은 Ki가 1.02nM인 강력한 세로토닌 운반체(SERT) 억제제입니다.

  • GC65209 structure
    GC65209Imipramine-d4 hydrochloride
    CAS: 61361-33-9
    Purity: >99.50%
  • GC69880 structure
    GC69880SERT-IN-2
    CAS: 2055228-33-4
    Purity: >98.00%

    SERT-IN-2는 강력한 SERT 억제제(IC50=0.58 nM)로, 항우울 활성을 가지고 있습니다. SERT-IN-2의 생체 이용도는 좋으며, 쥐에서 F(%)는 83.28%입니다. 또한 SERT-IN-2는 혈뇌 장벽을 통과할 수 있습니다.

  • GC70178 structure
    GC70178ZZL-7
    CAS: 99141-91-0
    Purity: >98.00%

    ZZL-7는 빠른 효과를 가진 항우울제입니다. ZZL-7은 중심선반핵(DRN) 내의 세로토닌 수송체(SERT)와 신경원소 일산화질소 합성효소(nNOS) 간 상호작용을 파괴함으로써 작용합니다. ZZL-7은 혈뇌장벽을 쉽게 통과하여 중증우울증(MDD) 연구에 사용될 수 있습니다.

  • GC70271 structure
    GC70271Ampreloxetine hydrochloride
    CAS: 1227056-87-2
    Purity: >99.00%

    Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT).

  • GC71618 structure
    GC71618rel-Sertraline-d3 hydrochloride
    CAS: 1330180-66-9

    rel-Sertraline-d3 hydrochloride는 Sertraline 염산염으로 표기된 중수소입니다.

  • GC71620 structure
    GC71620Venlafaxine-d6
    CAS: 1020720-02-8

    Venlafaxine-d6는 벤라팍신 (Venlafaxine)으로 표기된 중수소이다.

  • GC79505 structure
    GC79505RPI-GLYT2-82
    Purity: >99.00%

    RPI-GLYT2-82 is a reversible, blood-brain barrier-permeable allosteric inhibitor of GlyT2 with an IC 50 value of 554 nM.

  • GC79780 structure
    GC79780SERT/5-HT-IN-1
    CAS: 3120534-54-2
    Purity: >99.00%

    SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A ( SERT IC 50 = 1.5 nM, NET IC 50 = 49 nM, DAT IC 50 = 91 nM, 5-HT3A K i = 12 nM).

  • GC79790 structure
    GC79790A6CDQ
    CAS: 1005550-46-8
    Purity: >98%

    A6CDQ is a human organic cation transporter ( hOCT ) inhibitor with antidepressant-like activity that can cross the blood-brain barrier.