Apoptosis

PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1.

Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .

PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC 50 of 20 nM against PDGFRA, a K i of 93.3 nM against CA IX, and a K i of 80.0 nM against CA XII.

FGF7p is a small molecule peptide and a potential bladder protector.

GZD-552 is a potent orally active FAK inhibitor with a human FAK IC 50 of 5.8 nM.

MST3-IN-1 TFA (Compound LD-1) is a selective and orally active MST3 inhibitor, with an IC 50 of 122.4 nM.

THR-123 TFA is an orally active ALK3 peptide agonist.

8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) trisodium solution (100mM) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E.

ARF(26-44), cell-permeable acetate is a cell-penetrating peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein.

ALDOA-IN-1 is an aldolase A (ALDOA) inhibitor.

FOXM1-IN-3 is a potent FOXM1 inhibitor.

FPP29 is a potent peptide-based FOXM1 PROTAC degrader.

SKLB06489 is a selective and orally active inhibitor of type I PRMT enzymes, with IC 50 values of 64.55 nM ( PRMT1 ), 4.21 nM ( PRMT6 ), and 51.27 nM ( PRMT8 ).

CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC 50 of 1250 nM.

dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM.

WWZ-11-098 is a selective CDK6 PROTAC degrader with DC 50 of 2.6 nM.

Auristatin S TFA is a potent Auristatin payload.

iMQT_020 is a selective allosteric SLC1A5_var inhibitor.

Geranyl isovalerate is a chemical component that can be extracted from Argyreia Nervosa.

CIGB-552 TFA is a cell-penetrating peptide with anti-tumor properties with the IC 50 of 23 μM in H460 cells.

14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC 50 of 15 nM.

ZNF281-IN-1 is a ZNF281 inhibitor.

ANT308 TFA is a vasoactive intestinal polypeptide ( VIP receptor ) antagonist.

Maxadilan TFA is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies.