GLPBio

Complement System

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The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system. Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.

Products Related to Complement System(69)

  • GC72326 structure
    GC72326Riliprubart
    CAS: 2756228-76-7
    Purity: >99.00%

    Riliprubart (SAR445088) 는 고전적인 보체 시스템의 근단 부분의 활성화 C1s를 억제하는 항C1s 인적 자원화 단일 클론 항체이다.

  • GC72354 structure
    GC72354Lampalizumab
    CAS: 1278466-20-8
    Purity: >99.00%

    Lampalizumab (RG 7417)은 대체 보완 경로의 보완 인자 D를 목표로 하는 인간화 단일 클론 항체이다.

  • GC72391 structure
    GC72391Avdoralimab
    CAS: 2226393-85-5
    Purity: >95.00%

    Avdoralimab (IPH 5401) 는 C5a와의 결합을 막는 표적 보체인 C5a 수용체 1 (C5aR1) 인 전인IgG 단일 클론 항체이다.

  • GC72473 structure
    GC72473Crovalimab
    CAS: 1917321-26-6
    Purity: >98.00%

    Crovalimab (SKY59; RO7112689) 는 pH 의존성을 가진 새로운 인간화 C5 항체로 pH 7.4와 5.8에서 KD는 각각 15.2nM과 16.8μM이었다.

  • GC73106 structure
    GC73106Cemdisiran sodium
    Purity: >96.00%

    Cemdisiran sodium 는 간에서 보체 5 (C5) 단백질이 생성되는 것을 억제하여 보체가 매개하는 질병을 연구하기 위해 N-아세틸반유당아민 (GalNAc) 이 짝으로 연결된 siRNA이다.

  • GC73413 structure
    GC73413ARC186 sodium
    Purity: >94.00%

    ARC186 sodium는 0 Avacincaptad pegol ARC1905 sodium과 동일한 염기서열을 갖는 미결합 40KDa PEG 압타머이다.

  • GC74045 structure
    GC74045Zoracopan
    CAS: 2243483-63-6
    Purity: >99.00%

    Zoracopan 는 선택적 보체인자 D (CFD) 억제제입니다.

  • GC74354 structure
    GC74354Pegcetacoplan acetate
    Purity: >98.00%

    Pegcetacoplan acetate 는 폴리에틸렌글리콜화 된 보체 C3 억제제 펩타이드입니다.

  • GC74552 structure
    GC74552Gefurulimab
    CAS: 2456407-94-4
    Purity: >97.00%

    Gefurulimab (ALXN-1720) 는 C5를 결합하고 활성화를 차단하는 보체 C5와 백단백질에 대한 사람에게서 유래한 이중 특이성 항체이다.

  • GC74590 structure
    GC74590Pozelimab
    CAS: 2096328-94-6
    Purity: >99.00%

    Pozelimab (REGN3918) 는 전인IgG4 항C5 단일클론항체이다.

  • GC79355 structure
    GC79355SAR-443809
    Purity: >97.00%

    SAR-443809 is a monoclonal antibody targeting complement factor Bb that inhibits the alternative complement pathway.

  • GC79356 structure
    GC79356Ascuprubart
    CAS: 3056020-15-3
    Purity: >97.50%

    Ascuprubart is an anti-human monoclonal antibody targeting Complement C5.

  • GC79357 structure
    GC79357ANX-M1 (Human IgG1)
    Purity: >99.00%

    ANX-M1 is a blood-brain barrier-permeable anti- C1q antibody.

  • GC79358 structure
    GC79358Lexucitug
    CAS: 3058391-51-5
    Purity: >98.00%

    Lexucitug (DCSZ-11) is a humanized monoclonal antibody targeting CD93.

  • GC79359 structure
    GC79359RPARPAR acetate
    Purity: >99.00%

    RPARPAR acetate is a CendR tumor-penetrating peptide.

  • GC79360 structure
    GC79360Pulchinenoside J
    CAS: 1476801-10-1
    Purity: >98%

    Pulchinenoside J is a lupane-type triterpenoid saponin and a complement system inhibitor that acts via the classical pathway.

  • GC79361 structure
    GC79361Vonaprument
    CAS: 3050549-24-8
    Purity: >98%

    Vonaprument (ANX-007) is an intravitreally injected C1q antibody fragment (with a molecular weight of approximately 48 kDa) and a human monoclonal antibody.

  • GC79362 structure
    GC79362Anti-CD55 Antibody
    Purity: >99.50%

    Anti-CD55 Antibody is an anti- CD55 antibody.

  • GC79418 structure
    GC79418NRPa-308
    CAS: 717863-53-1
    Purity: >98.50%

    NRPa-308 is a potent and orally active Neuropilin-1 (NRP-1) antagonist with an IC 50 of 42 μM for inhibiting VEGF-A 165 binding to NRP-1.

  • GC81483 structure
    GC81483AKIR001
    Purity: >99.00%

    AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6.

  • GF10303 structure
    GF10303Lipoteichoic acid
    CAS: 56411-57-5

    Lipoteichoic acid은 그람양성균의 세포벽에 주로 위치하는 테이코산으로 면역 반응 및 세포 신호 전달 경로를 자극하기 위해 일반적으로 관여한다.