Reactive Oxygen Species
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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products Related to Reactive Oxygen Species(505)
- GC81631WollastoniteCAS: 13983-17-0Purity: >98.00%
Wollastonite is a white, chain-structured pyroxene silicate mineral with biocompatibility, biodegradability, osteogenicity and antibacterial properties.
- GC816326-Carboxy-H2DCFDACAS: 247044-02-6Purity: >95.00%
6-Carboxy-H2DCFDA (6-Carboxy-2',7'-dichlorodihydrofluorescein) is a non-fluorescent, cell-permeable intracellular ROS indicator.
- GC816342-Acetamidophenol-d 3CAS: 122258-87-1Purity: >99.00%
2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol.
- GC81638PROTAC GPX4 degrader-5CAS: 3119292-91-7Purity: >95.00%
PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM).
- GC81695DIM-3,5-Cl2CAS: 2595179-74-9Purity: >99.00%
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively.
- GC817528-DeoxylactucinCAS: 65725-10-2Purity: >95.00%
8-Deoxylactucin is an orally active sesquiterpene lactone.
- GC81758HDAC11-IN-5Purity: >98.00%
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM.
- GC81760ShepherdineCAS: 3000-36-0Purity: >98.00%
Shepherdine, a harmala-type indole and tetrahydro-β-carboline alkaloid, is an antioxidant.
- GC81763Coelenterazine TFAPurity: >99.00%
Coelenterazine TFA is a luminescent enzyme substrate for apoaequorin and Renilla luciferase.
- GC81767BAY-1128688CAS: 1428988-21-9Purity: >98.00%
BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC 50 < 2 nM.
- GC81771RANKL-IN-1 formatePurity: >99.50%
RANKL-IN-1 formate is a selective receptor activator of nuclear factor-κB ligand inhibitor ligand ( RANKL ) inhibitor with a K D value of 7.6 μM.
- GC81873Ciprofloxacin hydrochlorideCAS: 86483-48-9Purity: >98.00%
Ciprofloxacin hydrochloride (Bay-09867 hydrochloride) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent.
- GC81880OSU-2S TFAPurity: >98.00%
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC81631 | Wollastonite | 13983-17-0 | >98.00% | |
Wollastonite is a white, chain-structured pyroxene silicate mineral with biocompatibility, biodegradability, osteogenicity and antibacterial properties. | ||||
| GC81632 | 6-Carboxy-H2DCFDA | 247044-02-6 | >95.00% | |
6-Carboxy-H2DCFDA (6-Carboxy-2',7'-dichlorodihydrofluorescein) is a non-fluorescent, cell-permeable intracellular ROS indicator. | ||||
| GC81634 | 2-Acetamidophenol-d 3 | 122258-87-1 | >99.00% | |
2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol. | ||||
| GC81638 | PROTAC GPX4 degrader-5 | 3119292-91-7 | >95.00% | |
PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM). | ||||
| GC81639 | SH-26 | - | >98% | |
SH-26 is a PHD1 PROTAC degrader with DC 50 s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. | ||||
| GC81695 | DIM-3,5-Cl2 | 2595179-74-9 | >99.00% | |
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively. | ||||
| GC81752 | 8-Deoxylactucin | 65725-10-2 | >95.00% | |
8-Deoxylactucin is an orally active sesquiterpene lactone. | ||||
| GC81758 | HDAC11-IN-5 | - | >98.00% | |
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM. | ||||
| GC81760 | Shepherdine | 3000-36-0 | >98.00% | |
Shepherdine, a harmala-type indole and tetrahydro-β-carboline alkaloid, is an antioxidant. | ||||
| GC81762 | Mitoflaxone | 87626-55-9 | >99.50% | |
| GC81763 | Coelenterazine TFA | - | >99.00% | |
Coelenterazine TFA is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. | ||||
| GC81767 | BAY-1128688 | 1428988-21-9 | >98.00% | |
BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC 50 < 2 nM. | ||||
| GC81771 | RANKL-IN-1 formate | - | >99.50% | |
RANKL-IN-1 formate is a selective receptor activator of nuclear factor-κB ligand inhibitor ligand ( RANKL ) inhibitor with a K D value of 7.6 μM. | ||||
| GC81846 | Nivitol | 869743-37-3 | >98.00% | |
Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor. | ||||
| GC81873 | Ciprofloxacin hydrochloride | 86483-48-9 | >98.00% | |
Ciprofloxacin hydrochloride (Bay-09867 hydrochloride) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. | ||||
| GC81880 | OSU-2S TFA | - | >98.00% | |
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720). | ||||
| GC90533 | (-)-Pinoresinol | 81446-29-9 | >95.00% | |
다양한 생물학적 활동을 가진 리그난 | ||||
| GC90655 | Lentztrehalose B | 1808096-67-4 | >80.00% | |
다양한 생물학적 활동을 가진 이종당류 미생물 대사산물 | ||||
| GC90889 | 5-(3'-Hydroxyphenyl)-γ-Valerolactone | 21618-91-7 | >95.00% | |
다양한 폴리페놀의 대사산물 | ||||
| GC91083 | Tiopronin-Cysteine Disulfide | 77591-18-5 | >95.00% | |
티오프로닌의 대사산물 | ||||
| GC91099 | HUP-55 | - | >98.00% | |
프롤릴 엔도펩타이제 억제제 | ||||
| GC91590 | DTPD-Q | 252950-56-4 | >98.00% | |
DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD. | ||||
| GC91598 | GPX4 16 | 2644044-43-7 | >98.00% | |
GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4). | ||||
| GC91673 | CPPD-Q | 68054-78-4 | >98.00% | |
CPPD-Q is an oxidized derivative of the antioxidant CPPD, possessing antibacterial and insecticidal effects. | ||||