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Dehydrogenase

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Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Products Related to Dehydrogenase(36)

  • GC16816 structure
    GC16816Galloflavin
    CAS: 568-80-9
    Purity: >98.00%

    갈로플라빈은 강력한 젖산 탈수소효소(LDH) 억제제입니다. 피루브산에 대해 계산된 Kis는 5.46μM(LDH-A) 및 15.06μM(LDH-B)입니다. 갈로플라빈은 해당과정과 ATP 생성을 차단하여 암세포의 증식을 억제합니다.

  • GC16860 structure
    GC16860NCT-502
    CAS: 1542213-00-2
    Purity: >99.00%

    NCT-502는 인간 PHGDH(포스포글리세르산 탈수소효소) 억제제로 PHGDH 의존성 암세포에 세포독성이 있으며 PHGDH에 대한 IC50이 3.7μM로 포도당 유래 세린 생성을 감소시킨다.

  • GC16951 structure
    GC16951Stiripentol
    CAS: 49763-96-4
    Purity: >99.50%

    스티리펜톨(STP)은 항경련제로 CYP3A4(비경쟁) 및 CYP2C19(경쟁)에 의해 매개되는 CLB의 N-탈메틸화를 NCLB로 억제할 수 있으며 Ki는 각각 1.59±0.07 및 0.516±0.065 μM 및 IC580입니다. .

  • GC17107 structure
    GC17107PluriSIn #1 (NSC 14613)
    CAS: 91396-88-2
    Purity: >99.50%

    A selective inhibitor of stearoyl-CoA desaturase

  • GC17293 structure
    GC17293PHGDH-inactive
    CAS: 1914971-16-6
    Purity: >99.50%

    PHGDH 비활성은 PHGDH에 대한 활성이 없으며 NCT-502 및 NCT-503의 음성 대조군 역할을 합니다.

  • GC17467 structure
    GC17467Gimeracil
    CAS: 103766-25-2
    Purity: >99.50%

    A DYPD inhibitor

  • GC17914 structure
    GC17914Fomepizole
    CAS: 7554-65-6
    Purity: >99.50%

    포메피졸(4-메틸피라졸)은 강력한 시토크롬 P450(CYP2E1) 억제제입니다.

  • GC25039 structure
    GC25039AG-120 (racemic)
    CAS: 1448346-63-1
    Purity: >98%

    AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.

  • GC25389 structure
    GC25389Ethyl potassium malonate
    CAS: 6148-64-7
    Purity: >98%

    Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.

  • GC50508 structure
    GC50508PKUMDL WQ 2101
    CAS: 304481-72-9
    Purity: >98%

    Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

  • GC50509 structure
    GC50509PKUMDL WQ 2201
    CAS: 592474-91-4
    Purity: >98%

    Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

  • GC81900 structure
    GC81900CP61 acetate
    Purity: >98.50%

    CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH binding, disrupting the NADH -dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation.