GLPBio

Factor Xa

Read More about this category

Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Products Related to Factor Xa(59)

  • GC46879 structure
    GC46879Argatroban-d3 (hydrochloride)
    CAS: 1356847-56-7
    Purity: >99.00%

    An internal standard for the quantification of argatroban

  • GC47165 structure
    GC47165Dabigatran etexilate-d13
    CAS: 2749293-92-1
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC47280 structure
    GC47280Edoxaban-d6
    CAS: 1304701-57-2
    Purity: >99.00%

    An internal standard for the quantification of edoxaban

  • GC49118 structure
    GC4911810-hydroxy Warfarin
    CAS: 83219-99-2
    Purity: >95.00%

    A metabolite of (R)-warfarin

  • GC49131 structure
    GC49131Dehydro Warfarin
    CAS: 67588-18-5
    Purity: >95.00%

    A metabolite of (±)-warfarin

  • GC49322 structure
    GC49322GGACK (hydrochloride)
    Purity: >95.00%

    A uPA and factor Xa inhibitor

  • GC49518 structure
    GC49518Fluindione
    CAS: 957-56-2
    Purity: >98.00%

    A vitamin K antagonist

  • GC49614 structure
    GC49614Acenocoumarol-d4
    CAS: 2937878-24-3
    Purity: >99.00%

    Acenocoumarol-d4는 Acenocoumarol로 표시된 중수소입니다.

  • GC49682 structure
    GC49682Dabigatran-d3
    CAS: 1246817-44-6
    Purity: >99.00%

    An internal standard for the quantification of dabigatran

  • GC49684 structure
    GC49684Dabigatran-13C-d3
    CAS: 2967480-55-1
    Purity: >99.00%

    An internal standard for the quantification of dabigatran

  • GC60326 structure
    GC60326Rivaroxaban D4
    CAS: 1132681-38-9
    Purity: >98%

    Rivaroxaban D4(BAY 59-7939 D4)는 Rivaroxaban이라고 표시된 중수소입니다.

  • GC61748 structure
    GC61748Betrixaban D6
    CAS: 2098655-51-5
    Purity: >98.50%

    Betrixaban D6은 Betrixaban이라고 표시된 중수소입니다.

  • GC62298 structure
    GC62298Edoxaban impurity 4
    CAS: 480452-36-6
    Purity: >98%

    에독사반 불순물 4는 에독사반의 불순물이다.

  • GC62439 structure
    GC62439Edoxaban impurity 6
    CAS: 480452-37-7
    Purity: >98%
  • GC62922 structure
    GC62922Darexaban
    CAS: 365462-23-3
    Purity: >99.50%

    Darexaban(YM150)은 54.6 nM의 IC50을 가진 강력하고 선택적이고 경구 활성인 Xa 인자(FXa) 억제제입니다.

  • GC63873 structure
    GC63873Milvexian
    CAS: 1802425-99-5
    Purity: >98%

    효과적인 항혈전제인 Milvexian(BMS-986177)은 Ki가 각각 0.11 및 0.38 nM인 인간 및 토끼 인자 XIa(FXIa)의 경구 생체이용성, 가역성 및 직접 억제제입니다.

  • GC65060 structure
    GC65060Fitusiran
    CAS: 1499251-18-1
    Purity: >94.50%

    작은 간섭 RNA인 Fitusiran(ALN-AT3SC)은 특히 antithrombin(AT) 메신저 RNA를 표적으로 하여 간에서 AT 생성을 낮춥니다.

  • GC65912 structure
    GC65912Asundexian
    CAS: 2064121-65-7
    Purity: >99.50%

    Asundexian(BAY 2433334)은 경구 활성 응고 인자 Xia(FXIa) 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8Asundexian은 FXIa의 활성 부위에 직접적이고 강력하며 가역적으로 결합하여 그 활성을 억제합니다. 821d96072c2d58d8970e76f526b0f6b8Asundexian은 1nM의 IC50으로 버퍼에서 인간 FXIa를 억제합니다.821d96072c2d58d8970e76f526b0f6b8

  • GC68034 structure
    GC68034Enoxaparin
    CAS: 679809-58-6
    Purity: >98%
  • GC68593 structure
    GC68593Abelacimab
    CAS: 2098724-83-3
    Purity: >98%

    Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic domain of FXI and locks it in the zymogen conformation, preventing its activation by either FXIIa or thrombin. Abelacimab can be used for research on thrombotic diseases.

  • GC68778 structure
    GC68778BMS-262084
    CAS: 253174-92-4
    Purity: >98.00%

    BMS-262084는 인간 요인 XIa의 IC50 값이 2.8 nM인 효과적이고 선택적이며 불가역적인 팩터 XIa 억제제입니다. BMS-262084는 또한 인간 췌장 효소를 억제합니다 (IC50=5 nM). BMS-262084는 항혈전 작용을 가지고 있습니다.

  • GC69151 structure
    GC69151Garadacimab
    CAS: 2162134-62-3
    Purity: >95.00%

    Garadacimab (CSL312) is a first-in-class fully human IgG4 monoclonal antibody that targets activated factor XII (FXIIa). Garadacimab has the potential for use in research on hereditary angioedema.

  • GC70535 structure
    GC70535Zifaxaban
    CAS: 1378266-98-8

    Zifaxaban 는 경구용 활성, 경쟁성 및 선택성의 인자 Xa(FXa) 억제제로서 사람 FXa에 대한 IC50은 11.1nM이다.

  • GC70672 structure
    GC70672Fitusiran sodium
    Purity: >94.00%

    Fitusiran sodium, 간에서 AT 생성을 낮추기 위해 작은 간섭 RNA, 특이성 표적 항응고 효소 (AT) 메신저 RNA.