Ligand for Target Protein for PROTAC
The PROTAC molecule consists of a ligand, which binds the target protein, connected by a linker to another ligand that binds the E3 ubiquitin ligase.
The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.
Products Related to Ligand for Target Protein for PROTAC(49)
- GC63443Piperidine-GNE-049-N-BocCAS: 1936431-36-5Purity: >98.50%
Piperidine-GNE-049-N-Boc은 dCBP-1의 PROTAC에 대한 표적 단백질 리간드입니다. dCBP-1은 p300/CBP의 강력하고 선택적인 이종이기능성 분해제입니다.
- GC63536BMS-1166-N-piperidine-COOHCAS: 2447066-00-2Purity: >98%
BMS-1166-N-피페리딘-COOH, BMS-1166 기반 부분은 링커를 통해 E3 리가제 리간드에 결합하여 PROTAC PD-1/PD-L1 분해자-1을 형성하여 PD-1/PD-L1을 분해합니다. BMS-1166은 IC50이 1.4nM인 강력한 PD-1/PD-L1 상호작용 억제제입니다. BMS-1166은 T 세포 활성화에 대한 PD-1/PD-L1 면역 체크포인트의 억제 효과를 길항합니다.
- GC73032PROTAC BRD4 ligand-2 hydrochloridePurity: >99.00%
PROTAC BRD4 ligand-2 hydrochloride는 PROTAC CFT-2718에 대한 표적 BRD4단백질을위한 리간드입니다.
- GC74133SMARCA-BD ligand 1 for PROTAC hydrochlorideCAS: 2380272-56-8Purity: >99.00%
SMARCA-BD ligand 1 for PROTAC hydrochloride은 BAF ATPase subunits SMARCA2에 결합하는 화합물이며, PROTAC 기반의 SMARCA2를 분해하는데 사용된다.
- GC74139AZD9496 deacrylic acid phenolCAS: 2173404-70-9Purity: >96.00%
AZD9496 deacrylic acid phenol은 PROTAC ER Degrader-4의 표적 단백질 배합체 조각입니다.
- GC80878RIPK2 ligand 3CAS: 2027561-86-8Purity: >99.00%
RIPK2 ligand 3 is a RIPK2 ligand and can be used for the synthesis of PROTACs, such as PROTAC RIPK degrader-2 [1] .
- GC80925KAT2A/B ligand 1CAS: 2254066-18-5Purity: >99.00%
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand.
- GC80926BI-7273 acidCAS: 2097514-90-2Purity: >98.00%
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand.
- GC80927NSD2 ligand 2CAS: 3031353-62-2Purity: >98.50%
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2.
- GC80942IRF4 ligand-1CAS: 3113827-15-6Purity: >99.00%
IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 [1] .
- GC80947JAK1/2 ligand 1CAS: 1026028-96-5Purity: >99.50%
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.
- GC81020JNK1 ligand-1-NH-Ph-COOHCAS: 3047792-63-9Purity: >98.00%
JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor.
- GC81021p38α ligand-1CAS: 586379-64-8Purity: >98.50%
P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] .
- GC81042PI3K/mTOR ligand-1CAS: 1197160-66-9Purity: >97.00%
PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ).
- GC81299c-Met ligand-1CAS: 1103506-79-1Purity: >98%
c-Met ligand-1 is a c-Met ligand and component of c-Met PROTAC degrader [1] .
- GC81513SMARCA2/4-ligand-8CAS: 2380272-41-1Purity: >99.50%
SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 [1] .
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC63443 | Piperidine-GNE-049-N-Boc | 1936431-36-5 | >98.50% | |
Piperidine-GNE-049-N-Boc은 dCBP-1의 PROTAC에 대한 표적 단백질 리간드입니다. dCBP-1은 p300/CBP의 강력하고 선택적인 이종이기능성 분해제입니다. | ||||
| GC63536 | BMS-1166-N-piperidine-COOH | 2447066-00-2 | >98% | |
BMS-1166-N-피페리딘-COOH, BMS-1166 기반 부분은 링커를 통해 E3 리가제 리간드에 결합하여 PROTAC PD-1/PD-L1 분해자-1을 형성하여 PD-1/PD-L1을 분해합니다. BMS-1166은 IC50이 1.4nM인 강력한 PD-1/PD-L1 상호작용 억제제입니다. BMS-1166은 T 세포 활성화에 대한 PD-1/PD-L1 면역 체크포인트의 억제 효과를 길항합니다. | ||||
| GC63717 | PROTAC Bcl-xL ligand-1 | - | >98% | |
PROTAC Bcl-xL 리간드-1은 PROTAC 합성에 사용할 수 있는 Bcl-xL의 리간드입니다. | ||||
| GC67770 | Tazemetostat de(methyl morpholine)-COOH | 2685873-44-1 | >98.00% | |
| GC68434 | Dimethyl-F-OICR-9429-COOH | 2407458-49-3 | >98.00% | |
| GC73032 | PROTAC BRD4 ligand-2 hydrochloride | - | >99.00% | |
PROTAC BRD4 ligand-2 hydrochloride는 PROTAC CFT-2718에 대한 표적 BRD4단백질을위한 리간드입니다. | ||||
| GC73331 | BMS-37 | 1675202-20-6 | >98.00% | |
BMS-37는 PD-1/PD-L1 면역 체크포인트 억제제이다. | ||||
| GC73510 | (S)-SKBG-1 | 2955618-24-1 | >99.00% | |
(S)-SKBG-1은 비활성 및 공유 노노 리간드로 검사 제어에 사용됩니다. | ||||
| GC74133 | SMARCA-BD ligand 1 for PROTAC hydrochloride | 2380272-56-8 | >99.00% | |
SMARCA-BD ligand 1 for PROTAC hydrochloride은 BAF ATPase subunits SMARCA2에 결합하는 화합물이며, PROTAC 기반의 SMARCA2를 분해하는데 사용된다. | ||||
| GC74139 | AZD9496 deacrylic acid phenol | 2173404-70-9 | >96.00% | |
AZD9496 deacrylic acid phenol은 PROTAC ER Degrader-4의 표적 단백질 배합체 조각입니다. | ||||
| GC79788 | BTA-1_b | 95856-73-8 | >98.00% | |
BTA-1 _b (BTA-1-CH3) is a structural analog of BTA-1. | ||||
| GC80878 | RIPK2 ligand 3 | 2027561-86-8 | >99.00% | |
RIPK2 ligand 3 is a RIPK2 ligand and can be used for the synthesis of PROTACs, such as PROTAC RIPK degrader-2 [1] . | ||||
| GC80925 | KAT2A/B ligand 1 | 2254066-18-5 | >99.00% | |
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand. | ||||
| GC80926 | BI-7273 acid | 2097514-90-2 | >98.00% | |
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand. | ||||
| GC80927 | NSD2 ligand 2 | 3031353-62-2 | >98.50% | |
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2. | ||||
| GC80942 | IRF4 ligand-1 | 3113827-15-6 | >99.00% | |
IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 [1] . | ||||
| GC80947 | JAK1/2 ligand 1 | 1026028-96-5 | >99.50% | |
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1. | ||||
| GC81020 | JNK1 ligand-1-NH-Ph-COOH | 3047792-63-9 | >98.00% | |
JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor. | ||||
| GC81021 | p38α ligand-1 | 586379-64-8 | >98.50% | |
P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] . | ||||
| GC81023 | 5-Iodo-BIIB021 | 911397-54-1 | >98.00% | |
5-Iodo-BIIB021 is a HSP90 ligand. | ||||
| GC81042 | PI3K/mTOR ligand-1 | 1197160-66-9 | >97.00% | |
PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ). | ||||
| GC81299 | c-Met ligand-1 | 1103506-79-1 | >98% | |
c-Met ligand-1 is a c-Met ligand and component of c-Met PROTAC degrader [1] . | ||||
| GC81458 | TT-012-Br | - | >96.00% | |
TT-012-Br (Compound 4) is a ligand for MITF and can be used for the synthesis of PROTACs, such as WZS0347 [1] . | ||||
| GC81513 | SMARCA2/4-ligand-8 | 2380272-41-1 | >99.50% | |
SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 [1] . | ||||