BTA-1 _b (BTA-1-CH3) is a structural analog of BTA-1. BTA-1 is an uncharged derivative of Thioflavin-T. It exhibits high affinity for Aβ fibrils and demonstrates excellent brain penetration and clearance capabilities.
In Vitro, Structural analogs are frequently used as control compounds to distinguish whether the biological effects of a target molecule are mediated by specific target binding or by non-specific physicochemical properties.
References:
[1]. Tomoshige S, et al. Discovery of Small Molecules that Induce the Degradation of Huntingtin. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11530-11533.
[2]. Wu C, et. al. The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations. J Mol Biol. 2008 Dec 19;384(3):718-29.
In Vitro, Structural analogs are frequently used as control compounds to distinguish whether the biological effects of a target molecule are mediated by specific target binding or by non-specific physicochemical properties.
References:
[1]. Tomoshige S, et al. Discovery of Small Molecules that Induce the Degradation of Huntingtin. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11530-11533.
[2]. Wu C, et. al. The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations. J Mol Biol. 2008 Dec 19;384(3):718-29.