GLPBio

Acyltransferase

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DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

Products Related to Acyltransferase(69)

  • GC50570 structure
    GC50570ST 045849
    CAS: 442665-87-4
    Purity: >98.50%

    ST 045849는 O-GlcNAc 전이효소(OGT)의 억제제로 IC50 값이 53μM이다.

  • GC52256 structure
    GC52256CAY10794
    CAS: 1231243-91-6
    Purity: >98.00%

    An inhibitor of DGAT-1

  • GC52290 structure
    GC52290(R)-HTS-3
    CAS: 2771208-83-2
    Purity: >98.00%

    An inhibitor of LPCAT3

  • GC61631 structure
    GC61631Pactimibe
    CAS: 189198-30-9
    Purity: >98.00%

    Pactimibe(CS-505 유리 염기)는 IC50이 각각 4.9μM 및 3.0μM인 이중 ACAT1/2 억제제입니다.

  • GC61888 structure
    GC61888Pactimibe sulfate
    CAS: 608510-47-0
    Purity: >98.00%

    Pactimibe 황산염(CS-505)은 각각 4.9μM 및 3.0μM의 IC50을 갖는 이중 ACAT1/2 억제제입니다.

  • GC62428 structure
    GC62428Ervogastat
    CAS: 2186700-33-2
    Purity: >98.00%
  • GC62744 structure
    GC62744(Rac)-OSMI-1
    CAS: 2748153-92-4
    Purity: >96.00%

    (Rac)-OSMI-1은 OSMI-1의 라세미체입니다.

  • GC64687 structure
    GC64687BMS-963272
    CAS: 1441057-15-3
    Purity: >99.00%

    BMS-963272는 대사 장애 치료를 위한 강력한 선택적 MGAT2 억제제(IC50 = 7.1nM)입니다.

  • GC65200 structure
    GC65200Nevanimibe hydrochloride
    CAS: 133825-81-7
    Purity: >98.00%

    Nevanimibe 염산염(PD-132301 염산염)은 9nM의 EC50을 갖는 경구 활성 및 선택적 아실-조효소 A:콜레스테롤 O-아실트랜스퍼라제 1(ACAT1) 억제제입니다. Nevanimibe 염산염은 368nM의 EC50으로 ACAT2를 억제합니다. Nevanimibe 염산염은 세포 사멸을 유도하고 부신피질암의 가능성이 있습니다.

  • GC70245 structure
    GC70245CP-113818
    CAS: 135025-12-6
    Purity: >99.00%

    CP-113818는 강력한 콜레스테롤 아실 전달 효소 (ACAT) 억제제입니다.

  • GC70746 structure
    GC70746OSMI-2
    CAS: 2260542-60-5
    Purity: >98.00%

    OSMI-2(화합물 1b)는 세포가 침투할 수 있는 O-연결 N-아세틸글루코사민 전이효소(OGT) 억제제다.

  • GC71495 structure
    GC71495Lecimibide
    CAS: 130804-35-2

    Lecimibide (Dup 128) 는 고지혈증 연구에 사용되는 강력하고 특이한 아세틸 보조효소 a: 콜레스테롤 아세틸 전이효소(ACAT) 억제제입니다.

  • GC73626 structure
    GC73626PF-07202954
    CAS: 2639372-47-5
    Purity: >97.00%

    PF-07202954는 인간의 DGAT2에 대해 IC50이 10 nM인 약한 염기 DGAT2억제제이다.

  • GC74100 structure
    GC74100Eflucimibe
    CAS: 202340-45-2
    Purity: >99.50%

    Eflucimibe (F 12511) 는 새로운 아세틸 보조효소 a 콜레스테롤 O-아세틸 전이효소(ACAT) 억제제입니다.

  • GC74105 structure
    GC74105H2-003
    CAS: 1060438-30-3
    Purity: >99.00%

    H2-003는 트리글리세라이드 (TG) 생합성을 억제하는 선택적 인간 DGAT2억제제입니다.

  • GC79554 structure
    GC79554PF-06427878
    CAS: 1809064-23-0
    Purity: >98%

    PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 ( DGAT2 ) inhibitor with IC 50 s of 99 nM and 202 nM for human and rat DGAT2, respectively.

  • GC79555 structure
    GC79555Ent-Calquiquelignan E
    CAS: 1292294-31-5
    Purity: >98%

    Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound.

  • GC79556 structure
    GC79556SPT-IN-2
    CAS: 2035011-97-1
    Purity: >99.00%

    SPT-IN-2 is an orally active serine palmitoyltransferase ( SPT ) inhibitor (with an IC 50 of 0.71 nM against human SPT2 ).

  • GC79557 structure
    GC79557ST1060
    CAS: 1402702-76-4
    Purity: >96.50%

    ST1060 is a Ceramide synthase 2 ( CerS2 ) inhibitor.

  • GC79707 structure
    GC79707ST1072
    CAS: 1402703-50-7
    Purity: >98%

    ST1072 is an inhibitor of CerS4 and CerS6.

  • GC90472 structure
    GC90472Cyano-myracrylamide
    CAS: 2801702-34-9
    Purity: >98.00%

    zDHHC20 억제제