GLPBio

YAP

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The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased aberrantly. YAP enhances multiple processes known to be important for tumor progression and metastasis, including cellular proliferation, transformation, migration, and invasion.

Products Related to YAP(37)

  • GC73127 structure
    GC73127GNE-7883
    CAS: 2648450-42-2
    Purity: >98.00%

    GNE-7883 는 YAP/TAZ와 TEAD의 결합을 차단하는 범TEAD 억제제입니다.

  • GC73298 structure
    GC73298YTP-17
    Purity: >99.00%

    YTP-17는 4 nM의 IC50으로 구강 활성 YAP-TEAD 단백질-단백질 상호작용 억제제이다.

  • GC73349 structure
    GC73349YAP-TEAD-IN-2
    CAS: 2714432-83-2
    Purity: >98.00%

    YAP-TEAD-IN-2(화합물 6)는 강력한 YAP-TEAD PPI(단백질 상호작용) 억제제로, IC50은 2.7nM이다.

  • GC73457 structure
    GC73457IK-930
    CAS: 2563892-44-2
    Purity: >99.00%

    IK-930 (화합물 I-32) 는 EC50 수치 <0.1 µ M의 강력한 경구 TEAD 억제제입니다.

  • GC73562 structure
    GC73562LM-41
    CAS: 2996821-30-6
    Purity: >99.00%

    LM-41 는 CTGF, Cyr61, AxI 및 NF2의 발현을 현저하게 낮추는 플루페나산에서 파생된 TEAD 억제제입니다.

  • GC73564 structure
    GC73564SWTX-143
    CAS: 2766575-48-6
    Purity: >99.00%

    SWTX-143는 구강 활성 YAP/TAZ-TEAD 억제제로 4가지 TEAD 동소체 모두의 팔미토일화 포켓에 결합합니다.

  • GC73569 structure
    GC73569MY-1076
    CAS: 3008262-76-5
    Purity: >99.00%

    MY-1076 는 YAP의 억제제입니다.

  • GC73954 structure
    GC73954BAY-593
    CAS: 2413020-56-9
    Purity: >99.00%

    BAY-593 는 경구 활성 GGTase-I 억제제의 일종이다.

  • GC73955 structure
    GC73955(7S)-BAY-593
    CAS: 2413068-25-2
    Purity: >99.00%

    (7S)-BAY-593은 BAY-593의 S-대영 이구체다.

  • GC74115 structure
    GC74115YAP/TAZ inhibitor-3
    CAS: 2506273-81-8
    Purity: >99.00%

    YAP/TAZ inhibitor-3 (화합물 24) 는 YAP/TAZ 억제제입니다.

  • GC81347 structure
    GC81347YAP/TEAD-IN-2
    CAS: 2957895-40-6
    Purity: >95.00%

    YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor.

  • GC81349 structure
    GC81349(R,S)-YAP-TEAD-IN-2
    Purity: >98.00%

    (R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2.

  • GC81778 structure
    GC81778LATS-IN-2
    CAS: 2248728-49-4
    Purity: >99.00%

    LATS-IN-2 is an efficiently acting LATS ( large tumor suppressor kinase) inhibitor.