GLPBio

RVG Peptide (trifluoroacetate salt)

Catalog No.: GC92117Purity:>98.00%Synonyms: Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
COASDSData Sheet
RVG Peptide (trifluoroacetate salt)은 니코틴형 아세틸콜린 수용체(nAChR) 옹색제(인간 수용체에 대한 IC50=2.5μM)의 일종이다.

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

RVG Peptide (trifluoroacetate salt)
1 mgIn Stock
$69.00
1
5 mgIn Stock
$241.00
1
10 mgIn Stock
$378.00
1
25 mgIn Stock
$771.00
1
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인용 문헌 (Citations)

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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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제품 설명 (Description)

Rabies virus glycoprotein (RVG) peptide is a nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 2.5 ?M for the human receptor).1 Lipid nanoparticles (LNPs) conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats.2 LNPs conjugated to RVG peptide and encapsulating the iron chelator and prolyl hydroxylase inhibitor deferoxamine (DFO) reduce iron levels in the striatum and substantia nigra, as well as decrease levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increase levels of superoxide dismutase (SOD) in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease. RVG-containing and DFO-encapsulating LNPs also increase the latency to fall in the rotarod test in the same model.

References:
[1]. Lentz, T.L., Hawrot, E., and Wilson, P.T.Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptorProteins2(4)298-307(1987).
[2]. You, L., Wang, J., Liu, T., et al.Correction to targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in Parkinsonian miceACS Nano16(11)19605(2022).

제품 문서 (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

화학적 특성 (Chemical Properties)

동의어
Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
화학명
L-tyrosyl-L-threonyl-L-isoleucyl-L-tryptophyl-L-methionyl-L-prolyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-arginyl-L-prolylglycyl-L-threonyl-L-prolyl-L-cysteinyl-L-α-aspartyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-arginylglycyl-L-lysyl-L-arginyl-L-alanyl-L-seryl-L-asparaginyl-glycine, trifluoroacetate salt
SMILES
O=C(N[C@]([C@H](O[H])C)([H])C(N[C@@](C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(N[C@@H](CCSC)C(N3CCC[C@H]3C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N[H])=O)C(N4CCC[C@H]4C(N[C@@H](CCC/N=C(N[H])/N)C(N5CCC[C@H]5C(NCC(N[C@]([C@H](O[H])C)([H])C(N6CCC[C@H]6C(N[C@@H](CS[H])C(N[C@@H](CC(O)=O)C(N[C@@](C(N[C@H](C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CC(N[H])=O)C(NCC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC8=CC=C(O[H])C=C8)N[H].FC(F)(C(O)=O)F
분자식
C141H217N43O43S2 ? XCF3COOH
분자량
3266.6
용해도
DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml
보관
-20°C
일반 주의사항
제품의 용해도 데이터에 따라 적절한 용매를 선택하십시오. 조제 후에는 반복적인 동결·해동을 피할 수 있도록 저장 용액을 소분하십시오.
저장 용액은 -80°C 보관 시 6개월 이내, -20°C 보관 시 1개월 이내에 사용하십시오.
용해도를 높이려면 튜브를 37°C로 데운 뒤 적절한 시간 동안 초음파 처리하십시오.
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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