SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus ( CMV ) replication. SGC-CK1γ-1 can be used for the research of infection [1].
In Vitro, SGC-CK1γ-1 (5-10 μM, 2h) inhibits LRP6 phosphorylation levels in HEK293 cells[1]. SGC-CK1γ-1 (10 μM, 24-48 h) does not impact cell viability in HEK293 cells[1]. SGC-CK1γ-1 (1-10 μM) elicits anti-HCMV replication effects in HFF cells[1].
References:
[1]. Capener JL, et al. Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily. bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675406.
In Vitro, SGC-CK1γ-1 (5-10 μM, 2h) inhibits LRP6 phosphorylation levels in HEK293 cells[1]. SGC-CK1γ-1 (10 μM, 24-48 h) does not impact cell viability in HEK293 cells[1]. SGC-CK1γ-1 (1-10 μM) elicits anti-HCMV replication effects in HFF cells[1].
References:
[1]. Capener JL, et al. Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily. bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675406.