Solanidine (Synonyms: (–)-Solanidine, 22R,25S-Solanidine, NSC 76025) |
| Catalog No.GC52075 |
Solanidine은 Solanum demissum, Solanum acaule 및 Solanum tuberosum을 포함한 여러 감자 종에서 분리된 콜레스테인 알칼로이드입니다. 솔라니딘은 증식을 억제하고 명백한 항종양 효과를 나타낼 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80-78-4
Sample solution is provided at 25 µL, 10mM.
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Solanidine is a steroidal glycoalkaloid metabolite that has been found in potato (S. tuberosum) and has anticancer and teratogenic activities.1,2,3 It inhibits the growth of HT-29 colon and HepG2 liver cancer cells by 80.9 and 82.2%, respectively, when used at a concentration of 100 μg/ml.2 Solanidine (176 mg/kg) is teratogenic to hamster embryos when administered to pregnant dams on day eight of gestation.3
1.Nikolic, N.C., and Stankovic, M.Z.Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systemsJ. Agric. Food Chem.51(7)1845-1849(2003) 2.Lee, K.-R., Kozukue, N., Han, J.-S., et al.Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cellsJ. Agric. Food Chem.52(10)2832-2839(2004) 3.Gaffield, W., and Keeler, R.F.Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesisExperientia49(10)922-924(1993)
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