TREM2 agonist-3 (Compound 4i) is aTREM2agonist, with aKDvalue of 19.0 ?M. TREM2 agonist-3 shows aKDvalue of 39.8 ?M forTREM1. TREM2 agonist-3 induces an increase inphospho-SYKlevels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases andother diseasesinvolving TREM2 dysfunction[1].
References:
[1].Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.