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TSH Receptor

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The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid disease, is a target of both antigen-specific T cells and antibodies in patients with this condition. Autoantibodies to the TSHR (TSHR-Ab) act as thyroid stimulating factor (TSH) agonists in autoimmune hyperthyroidism (Robert Graves disease) but as TSH antagonists in autoimmune hypothyroidism (Hashimoto thyroiditis). The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity.

TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment.

TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function.

Products Related to TSH Receptor(10)

  • GC12956 structure
    GC12956ML224
    CAS: 1338824-21-7
    Purity: >98.50%

    ML224(NCGC00242364; ANTAG3)는 선택적 TSHR 역 효능제입니다. IC50 = 2.3μM으로 TSH 자극 cAMP 생산을 억제합니다.

  • GC19543 structure
    GC19543NCGC00379308
    CAS: 662164-09-2
    Purity: >98%

    NCGC00379308은 직접 TSHR 활성화에 의해 β-Arr 1의 전위를 시작하고 시험관 내에서 TSH 매개 전조골 분화를 강화하는 갑상선 자극 호르몬 수용체(TSHR)에 대한 양성 알로스테릭 조절제입니다.

  • GC26016 structure
    GC26016TSHR antagonist S37
    CAS: 1217616-61-9
    Purity: >98%

    TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).

  • GC31490 structure
    GC31490ML-109
    CAS: 1186649-91-1
    Purity: >99.00%

    ML-109는 40nM의 EC50을 가진 강력하고 완전한 갑상선 자극 호르몬 수용체(TSHR) 작용제입니다.

  • GC32423 structure
    GC32423Org41841
    CAS: 301847-37-0
    Purity: >99.00%

    Org41841은 황체형성 호르몬/융모막 성선 자극 호르몬 수용체(LHCGR)와 갑상선 자극 호르몬 수용체(TSHR)의 부분 효능제이며 EC50이 각각 0.2 및 7.7μM입니다.

  • GC62506 structure
    GC62506TSHR antagonist S37b
    CAS: 2143452-22-4
    Purity: >99.00%

    TSHR 길항제 S37b는 TSHR 길항제 S37a의 덜 효과적인 거울상 이성질체입니다.

  • GC62519 structure
    GC62519TSHR antagonist S37a
    CAS: 2143452-20-2
    Purity: >99.00%

    TSHR 길항제 S37a는 TSHR(고선택성 갑상선자극호르몬 수용체) 길항제로 그레이브스 안와병증의 치료 가능성이 있습니다.

  • GC64079 structure
    GC64079NCGC00229600
    CAS: 1338824-20-6
    Purity: >99.00%

    NCGC00229600은 갑상선 자극 호르몬 수용체(TSHR)의 알로스테릭 역 효능제입니다.

  • GC65946 structure
    GC65946VA-K-14 hydrochloride
    CAS: 1171341-19-7
    Purity: >98%

    VA-K-14 염산염은 특정 갑상선 자극 호르몬 수용체(TSHR) 길항제입니다(IC50= 12.3 μM).821d96072c2d58d8970e76f526b0f6b8

  • GC71446 structure
    GC71446SYD5115

    SYD5115은 구강 가능한 TSH-R 길항제입니다.