UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50 s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion [1].
In Vitro, UK122 (11.1-100 μM; 24 h) hydrochloride dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1]. UK122 (10-100 μM; 48 h) hydrochloride has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].
References:
[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.
In Vitro, UK122 (11.1-100 μM; 24 h) hydrochloride dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1]. UK122 (10-100 μM; 48 h) hydrochloride has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].
References:
[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.