VCAM1 binding peptide acetate

VCAM1 binding peptide acetate is a VCAM1 binder with internalization activity. VCAM1 binding peptide acetate can be labeled with 5-FAM. VCAM1 binding peptide acetate serves as a component of biosensing systems for visualizing in vitro VCAM1 endocytic pathways. VCAM1 binding peptide acetate forms the research and development basis for MacroP and NAMP, PET radiotracers targeting VCAM1. VCAM1 binding peptide acetate is applicable to studies related to atherosclerosis ^{[1] [2]}.

In Vitro, The binding intensity of 5FAM-labeled VCAM1-binding peptide (10 mM; 4 h) to TNFα-treated HUVEC is higher than that to control HUVEC^[1]. 68Ga-MacroP (a VCAM1-binding peptide conjugate) binds specifically to VCAM-1 on the surface of TNF-α-stimulated HUVECs, and the activated cellular radioactive uptake is 4-fold higher than that of unstimulated control cells^[2].

References:
[1]. Fu Y, et al. Endocytic pathway of vascular cell adhesion molecule 1 in human umbilical vein endothelial cell identified in vitro by using functionalized nontoxic fluorescent quantum dots[J]. Sensors and Actuators B: Chemical, 2019, 297: 126702.
[2]. Pastorino S, et al. Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting. Pharmaceutics. 2021;13(7):1025. Published 2021 Jul 6.