GLPBio

Kuraridine

Catalog No.: GC70519Purity:>98.00%
COASDSData Sheet
Kuraridine is a prenylated flavonol extract from the roots ofSophora flavescens.

Products are for research use only. Not for human use. We do not sell to patients.

Kuraridine
Cas No.: 34981-25-4
1 mgIn Stock
$315.00
1
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Description

Kuraridine is a prenylated flavonol extract from the roots ofSophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5(PDE5) (IC50=0.64 μM).

Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1].
Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2].
Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2].

References:
[1]. Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.
[2]. Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol Divers.2011 May;15(2):361-72.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
34981-25-4
Molecular Formula
C26H30O6
Molecular Weight
438.51
Solubility
DMSO : ≥ 100 mg/mL (228.04 mM)
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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