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Home >> Signaling Pathways >> Metabolism >> PDE

PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for  PDE

  1. Cat.No. Product Name Information
  2. GC34984 (R)-(-)-Rolipram (R)-(-)-Rolipram Chemical Structure
  3. GC50321 (S)-C33 Potent PDE9 inhibitor (S)-C33 Chemical Structure
  4. GC13956 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide phosphodiesterase 7 (PDE7) inhibitor 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide Chemical Structure
  5. GC60024 3-O-Methylquercetin 3-O-Methylquercetin Chemical Structure
  6. GC50419 A 33 Potent and selective PDE4B inhibitor A 33 Chemical Structure
  7. GC41269 Acetildenafil Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group. Acetildenafil Chemical Structure
  8. GC31213 AMG 579 AMG 579 Chemical Structure
  9. GC10859 Amino Tadalafil analog of tadalafil, a potent inhibitor of phosphodiesterase 5 Amino Tadalafil Chemical Structure
  10. GC12764 Aminophylline Pan-PDE inhibitor Aminophylline Chemical Structure
  11. GC42792 Amrinone Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM). Amrinone Chemical Structure
  12. GC11472 AN-2728 PDE4 inhibitor,anti-inflammatory compound AN-2728 Chemical Structure
  13. GC31728 AN3199 AN3199 Chemical Structure
  14. GC11273 Anagrelide HCl Thrombocytopenic agent Anagrelide HCl Chemical Structure
  15. GC10420 Apremilast (CC-10004)

    PDE4 inhibitor

     Apremilast (CC-10004) Chemical Structure
  16. GC62403 ATX inhibitor 5 ATX inhibitor 5 Chemical Structure
  17. GC30390 Autotaxin modulator 1 Autotaxin modulator 1 Chemical Structure
  18. GC38890 Autotaxin-IN-3 Autotaxin-IN-3 Chemical Structure
  19. GC16856 Avanafil PDE5 inhibitor Avanafil Chemical Structure
  20. GC60063 Ayanin Ayanin Chemical Structure
  21. GC19343 Balipodect TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Balipodect Chemical Structure
  22. GC64703 BAY 2666605 BAY 2666605 Chemical Structure
  23. GC19512 Bay 60-7550

    Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM

     Bay 60-7550 Chemical Structure
  24. GC30923 BAY 73-6691 ((R)-BAY 73-6691) BAY 73-6691 ((R)-BAY 73-6691) Chemical Structure
  25. GC30915 BAY 73-6691 racemate BAY 73-6691 racemate Chemical Structure
  26. GC16048 BC 11-38 Selective PDE11 inhibitor BC 11-38 Chemical Structure
  27. GC60074 BI-2545 BI-2545 Chemical Structure
  28. GC19068 BI-409306 BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 uM). BI-409306 Chemical Structure
  29. GC35543 BPN14770 BPN14770 Chemical Structure
  30. GC15472 BRL 50481 PDE7 inhibitor,potent and selective BRL 50481 Chemical Structure
  31. GC35565 Bucladesine calcium salt A membrane permeable selective activator of PKA Bucladesine calcium salt Chemical Structure
  32. GC10944 Butein Protein kinase inhibitor Butein Chemical Structure
  33. GC31915 BW-A 78U BW-A 78U Chemical Structure
  34. GC61508 CALP2 TFA CALP2 TFA Chemical Structure
  35. GC33337 CDC801 CDC801 Chemical Structure
  36. GC16632 CDP 840 hydrochloride PDE4 inhibitor,potent and selective CDP 840 hydrochloride Chemical Structure
  37. GC31786 CI-1044 (PD-189659) CI-1044 (PD-189659) Chemical Structure
  38. GC17598 Cilomilast

    Potent PDE4 inhibitor

     Cilomilast Chemical Structure
  39. GC10109 Cilostamide type III phosphodiesterase (PDE3) inhibitor Cilostamide Chemical Structure
  40. GC15890 Cilostazol PDE3 inhibitor Cilostazol Chemical Structure
  41. GC10542 CP 80633 PDE4 inhibitor CP 80633 Chemical Structure
  42. GC19111 CP671305 CP671305 is a potent, orally active, selective inhibitor of phosphodiesterase-4-D, and possesses high activities. CP671305 Chemical Structure
  43. GC34895 D159687 D159687 Chemical Structure
  44. GC13076 Deltarasin KRAS-PDEδ interaction inhibitor Deltarasin Chemical Structure
  45. GC12060 Deltarasin hydrochloride inhibitor of KRAS-PDEδ interaction, potent and selective Deltarasin hydrochloride Chemical Structure
  46. GC35837 Deltasonamide 2 (TFA) Deltasonamide 2 (TFA) Chemical Structure
  47. GC35838 Deltasonamide 2 hydrochloride Deltasonamide 2 hydrochloride Chemical Structure
  48. GC12824 Dibutyryl-cAMP, sodium salt Cell-permeable cAMP analog that activates cAMP-dependent protein kinases Dibutyryl-cAMP, sodium salt Chemical Structure
  49. GC62589 Difamilast Difamilast Chemical Structure
  50. GC17673 Dipyridamole PDE inhibitor Dipyridamole Chemical Structure
  51. GC62234 DNMDP DNMDP Chemical Structure
  52. GC13444 Doxofylline PDE inhibitor Doxofylline Chemical Structure
  53. GC13652 Dyphylline Pan-PDE inhibitor Dyphylline Chemical Structure
  54. GC10796 Eggmanone selective inhibitor of PDE4 Eggmanone Chemical Structure
  55. GC10004 Enoximone type III phosphodiesterase (PDE3) inhibitor Enoximone Chemical Structure
  56. GC62466 Ensifentrine Ensifentrine Chemical Structure
  57. GC39288 ent-Tadalafil ent-Tadalafil Chemical Structure
  58. GC30437 ER21355 ER21355 Chemical Structure
  59. GC12771 Etazolate hydrochloride PDE-4 inhibitor and selective GABA-A receptor modulator Etazolate hydrochloride Chemical Structure
  60. GC64005 FPFT-2216 FPFT-2216 Chemical Structure
  61. GC62977 FR-229934 FR-229934 Chemical Structure
  62. GN10231 Fraxin;Fraxoside; Paviin Extracted from White wax;Suitability:Hot water and hot ethanol;Store the product in sealed,cool and dry condition Fraxin;Fraxoside; Paviin Chemical Structure
  63. GC43715 Furamidine (hydrochloride) Furamidine is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1 over PRMT5, PRMT6, and PRMT4/coactivator-associated arginine methyltransferase 1 (CARM1) (IC50s = 9.4, 166, 283, and >400 μM, respectively). Furamidine (hydrochloride) Chemical Structure
  64. GC15189 Gisadenafil besylate PDE5 inhibitor Gisadenafil besylate Chemical Structure
  65. GC41486 Glaucine Glaucine is an alkaloid originally isolated from G. Glaucine Chemical Structure
  66. GC19168 GLPG1690 GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and Ki of 15 nM. GLPG1690 Chemical Structure
  67. GC36187 GSK 256066 Trifluoroacetate GSK 256066 Trifluoroacetate Chemical Structure
  68. GC14180 GSK256066 PDE4-inhibitor,selective and highly potent GSK256066 Chemical Structure
  69. GC14697 HA 130 autotaxin inhibitor HA 130 Chemical Structure
  70. GC10869 HA-155 autotaxin inhibitor HA-155 Chemical Structure
  71. GC64012 Hcyb1 Hcyb1 Chemical Structure
  72. GC11730 IBMX Phosphodiesterase inhibitor IBMX Chemical Structure
  73. GC13275 Ibudilast inhibitor of PDE4 Ibudilast Chemical Structure
  74. GN10278 Icariin

    A PDE5 inhibitor

     Icariin Chemical Structure
  75. GC32643 ICI 153110 ICI 153110 Chemical Structure
  76. GC11313 ICI 63197 PDE4 inhibitor ICI 63197 Chemical Structure
  77. GC60199 Ilexsaponin B2 Ilexsaponin B2 Chemical Structure
  78. GC13191 Irsogladine PDE4 inhibitor Irsogladine Chemical Structure
  79. GC33878 Irsogladine maleate (Dicloguamine maleate) Irsogladine maleate (Dicloguamine maleate) Chemical Structure
  80. GC30811 ITI214 ITI214 Chemical Structure
  81. GC30841 ITI214 free base ITI214 free base Chemical Structure
  82. GC32633 K134 (OPC33509) K134 (OPC33509) Chemical Structure
  83. GC31258 L791943 L791943 Chemical Structure
  84. GC32529 LAS-31180 LAS-31180 Chemical Structure
  85. GC62525 LEO 39652 LEO 39652 Chemical Structure
  86. GC38921 Lirimilast Lirimilast Chemical Structure
  87. GC36474 Lodenafil Lodenafil Chemical Structure
  88. GC36475 Lodenafil carbonate Lodenafil carbonate Chemical Structure
  89. GC36540 Mardepodect Mardepodect Chemical Structure
  90. GC36541 Mardepodect hydrochloride Mardepodect hydrochloride Chemical Structure
  91. GC16849 MBCQ cGMP-specific phosphodiesterase PDE V inhibitor MBCQ Chemical Structure
  92. GC13657 Mesopram PDE4 inhibitor, orally active Mesopram Chemical Structure
  93. GC14868 Milrinone PDE-3 inhibitor Milrinone Chemical Structure
  94. GC36616 Mirodenafil Mirodenafil Chemical Structure
  95. GC36617 Mirodenafil dihydrochloride Mirodenafil dihydrochloride Chemical Structure
  96. GC16072 ML-030 PDE4 inhibitor ML-030 Chemical Structure
  97. GC12878 MMPX calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor MMPX Chemical Structure
  98. GC39539 Moracin M Moracin M Chemical Structure
  99. GC11684 MY-5445 PDE5 inhibitor MY-5445 Chemical Structure
  100. GC63308 N-Desmethyl Sildenafil-d8 N-Desmethyl Sildenafil-d8 Chemical Structure
  101. GC11072 Nortadalafil PDE5 inhibitor Nortadalafil Chemical Structure

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