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Home >> Signaling Pathways >> Metabolism >> PDE

PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for  PDE

  1. Cat.No. Product Name Information
  2. GC34984 (R)-(-)-Rolipram

    (R)-(-)-Rolipram, (R)-Rolipram

     (R)-(-)-Rolipram is the R-enantiomer of Rolipram. (R)-(-)-Rolipram Chemical Structure
  3. GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM. (R)-Avanafil Chemical Structure
  4. GC67864 (R)-Irsenontrine

    (R)-E2027

     (R)-Irsenontrine Chemical Structure
  5. GC50321 (S)-C33 Potent PDE9 inhibitor (S)-C33 Chemical Structure
  6. GC70606 (S)-PF-04449613 (S)-PF-04449613 is the left-handed isomer of PF-04449613 . (S)-PF-04449613 Chemical Structure
  7. GC13956 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide

    2'-(5-chloro-2-nitrophenylthio)-Acetanilide

     2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 μM. 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide Chemical Structure
  8. GC60024 3-O-Methylquercetin

    NSC 154016, Quercetin 3-methyl ether

     3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin Chemical Structure
  9. GC50419 A 33 A 33 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. A 33 Chemical Structure
  10. GC41269 Acetildenafil

    Hongdenafil

     Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group. Acetildenafil Chemical Structure
  11. GC31213 AMG 579 AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. AMG 579 Chemical Structure
  12. GC10859 Amino Tadalafil analog of tadalafil, a potent inhibitor of phosphodiesterase 5 Amino Tadalafil Chemical Structure
  13. GC12764 Aminophylline A phosphodiesterase inhibitor and adenosine receptor antagonist Aminophylline Chemical Structure
  14. GC42792 Amrinone

    WIN 40,680

     Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM). Amrinone Chemical Structure
  15. GC11472 AN-2728

    Crisaborole

     A selective PDE4 inhibitor AN-2728 Chemical Structure
  16. GC31728 AN3199 AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM. AN3199 Chemical Structure
  17. GC11273 Anagrelide HCl

    BL 4162A, BMY 26538-01

     A PDE3 inhibitor Anagrelide HCl Chemical Structure
  18. GC68657 Andolast free base

    CR 2039 free base; Dizolast free base

    Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for research on asthma.

     Andolast free base Chemical Structure
  19. GC10420 Apremilast (CC-10004)

    APR, CC-10004

     An orally available PDE4 inhibitor Apremilast (CC-10004) Chemical Structure
  20. GC64973 ATX inhibitor 1 ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor. ATX inhibitor 1 Chemical Structure
  21. GC62403 ATX inhibitor 5 ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 Chemical Structure
  22. GC30390 Autotaxin modulator 1 Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 Chemical Structure
  23. GC38890 Autotaxin-IN-3 Autotaxin-IN-3 is a Autotaxin(ATX) inhibitor with an IC50 of 2.4 nM, compound 33, sourced from patent WO2018212534A1. Autotaxin-IN-3 Chemical Structure
  24. GC16856 Avanafil

    TA-1790

     A potent and selective PDE5 inhibitor Avanafil Chemical Structure
  25. GC60063 Ayanin Ayanin is a bioflavonoid isolated from Croton schiedeanus Schlecht. Ayanin Chemical Structure
  26. GC19343 Balipodect

    TAK-063

     TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Balipodect Chemical Structure
  27. GC64703 BAY 2666605 BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135). BAY 2666605 Chemical Structure
  28. GC19512 Bay 60-7550

    BAY 607550

     Bay 60-7550 is a potent inhibitor of Phosphodiesterase 2 (PDE2) purified from bovine heart with an IC50 value of 2.0±0.7nM. Bay 60-7550 Chemical Structure
  29. GC30923 BAY 73-6691 ((R)-BAY 73-6691)

    (R)-BAY 73-6691

     BAY 73-6691 ((R)-BAY 73-6691) ((R)-BAY 73-6691 ((R)-BAY 73-6691)) is a potent, brain penetrant, and selective PDE9A inhibitor. BAY 73-6691 ((R)-BAY 73-6691) Chemical Structure
  30. GC30915 BAY 73-6691 racemate BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. BAY 73-6691 racemate Chemical Structure
  31. GC16048 BC 11-38 Selective PDE11 inhibitor BC 11-38 Chemical Structure
  32. GC68758 BI 1015550

    BI 1015550 is an orally active PDE4B inhibitor with an IC50 value of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).

     BI 1015550 Chemical Structure
  33. GC60074 BI-2545 BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively. BI-2545 Chemical Structure
  34. GC19068 BI-409306

    BI-409306

     BI-409306 (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders. BI-409306 Chemical Structure
  35. GC35543 BPN14770

    BPN14770

     BPN14770 (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. BPN14770 Chemical Structure
  36. GC15472 BRL 50481 PDE7 inhibitor,potent and selective BRL 50481 Chemical Structure
  37. GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt Chemical Structure
  38. GC10944 Butein

    2’,3,4,4’tetrahydroxy Chalcone

     Protein kinase inhibitor Butein Chemical Structure
  39. GC31915 BW-A 78U BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U Chemical Structure
  40. GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA Chemical Structure
  41. GC61508 CALP2 TFA CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 ?M) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 TFA Chemical Structure
  42. GC74677 CD00509 CD00509 is a Tdp1 inhibitor, with an IC50 value of 0.71 μM. CD00509 Chemical Structure
  43. GC33337 CDC801 CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively. CDC801 Chemical Structure
  44. GC16632 CDP 840 hydrochloride

    GR259653X

     CDP 840 hydrochloride (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor. CDP 840 hydrochloride Chemical Structure
  45. GC31786 CI-1044 (PD-189659)

    PD-189659

     CI-1044 (PD-189659) is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively. CI-1044 (PD-189659) Chemical Structure
  46. GC17598 Cilomilast

    SB 207499

     A PDE4 inhibitor Cilomilast Chemical Structure
  47. GC10109 Cilostamide

    OPC 3689

     type III phosphodiesterase (PDE3) inhibitor Cilostamide Chemical Structure
  48. GC15890 Cilostazol

    OPC 13013, OPC 21, Pletaal, Pletal

     A PDE3A inhibitor Cilostazol Chemical Structure
  49. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  50. GC10542 CP 80633

    CP-80,633

     CP 80633 (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice. CP 80633 Chemical Structure
  51. GC19111 CP671305 CP671305 is a potent, orally active, selective inhibitor of phosphodiesterase-4-D, and possesses high activities. CP671305 Chemical Structure
  52. GC68910 Cudetaxestat

    BLD-0409

    Cudetaxestat (BLD-0409) is an effective orally active autotaxin inhibitor.

     Cudetaxestat Chemical Structure
  53. GC34895 D159687 D159687 is a selective PDE4D inhibitor. D159687 Chemical Structure
  54. GC13076 Deltarasin A KRAS inhibitor Deltarasin Chemical Structure
  55. GC12060 Deltarasin hydrochloride inhibitor of KRAS-PDEδ interaction, potent and selective Deltarasin hydrochloride Chemical Structure
  56. GC68958 Deltasonamide 1

    Deltasonamide 1 is a PDE6δ-KRas inhibitor. It can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for research on tumors.

     Deltasonamide 1 Chemical Structure
  57. GC68959 Deltasonamide 1 TFA

    Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for cancer research.

     Deltasonamide 1 TFA Chemical Structure
  58. GC65246 Deltasonamide 2 Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Deltasonamide 2 Chemical Structure
  59. GC35837 Deltasonamide 2 (TFA) Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Deltasonamide 2 (TFA) Chemical Structure
  60. GC35838 Deltasonamide 2 hydrochloride Deltasonamide 2 hydrochloride is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Deltasonamide 2 hydrochloride Chemical Structure
  61. GC12824 Dibutyryl-cAMP, sodium salt

    DC 2797

    Dibutyryl-cAMP, sodium salt, also known as Bucladesine, is a cell-permeable cyclic nucleotide analogue which mimics the action of endogenous cAMP and acts as a phosphodiesterase inhibitor.

     Dibutyryl-cAMP, sodium salt Chemical Structure
  62. GC62589 Difamilast

    OPA-15406

     Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast Chemical Structure
  63. GC17673 Dipyridamole

    NSC 515776, NSC 619103

     PDE inhibitor Dipyridamole Chemical Structure
  64. GC62234 DNMDP DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity. DNMDP Chemical Structure
  65. GC67967 Dovramilast

    CC-11050

     Dovramilast Chemical Structure
  66. GC13444 Doxofylline

    ABC 12/3, 2-(7'-Theophyllinemethyl)-1,3-dioxolane

     PDE inhibitor Doxofylline Chemical Structure
  67. GC71605 Doxofylline-d6 Doxofylline-d6 is the deuterium labeled Doxofylline. Doxofylline-d6 Chemical Structure
  68. GC13652 Dyphylline

    7-(2,3-Dihydroxypropyl)theophylline, Dilor, Diprophylline, Lufyllin, Neothyllin, NSC 14305, NSC 40844

     An adenosine receptor antagonist and phosphodiesterase inhibitor Dyphylline Chemical Structure
  69. GC10796 Eggmanone

    EGM1

     selective inhibitor of PDE4 Eggmanone Chemical Structure
  70. GC72795 EMD 53998 EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 Chemical Structure
  71. GC74117 endo CNTinh-03 Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). endo CNTinh-03 Chemical Structure
  72. GC10004 Enoximone

    MDL 17043

     type III phosphodiesterase (PDE3) inhibitor Enoximone Chemical Structure
  73. GC66042 Enpp-1-IN-14 ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity. Enpp-1-IN-14 Chemical Structure
  74. GC69069 Enpp-1-IN-16

    Enpp-1-IN-16 (Compound 54) is an ENPP1 inhibitor. Enpp-1-IN-16 has potential in cancer research, particularly in cases where there is high expression of ENPP1 or increased levels of cytoplasmic DNA. Enpp-1-IN-16 can also be used for other diseases mediated by ENPP1, such as bacterial or viral infections, insulin resistance and type II diabetes, chondrocalcinosis and osteoarthritis, calcium pyrophosphate deposition disorder (CPPD), hypophosphatasia and soft tissue calcification disorders.

     Enpp-1-IN-16 Chemical Structure
  75. GC73576 Enpp-1-IN-19 Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP drolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 Chemical Structure
  76. GC74032 Enpp-1-IN-20 Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC50 of 0.09 nM. Enpp-1-IN-20 Chemical Structure
  77. GC70908 Enpp-1-IN-5 Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). Enpp-1-IN-5 Chemical Structure
  78. GC73371 Enpp/Carbonic anhydrase-IN-2 Enpp/Carbonic andrase-IN-2 (compound 1i) is a potent Enpp and carbonic andrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 Chemical Structure
  79. GC62466 Ensifentrine

    RPL-554

     Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine Chemical Structure
  80. GC39288 ent-Tadalafil ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 ?M. ent-Tadalafil Chemical Structure
  81. GC30437 ER21355 ER21355 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases. ER21355 Chemical Structure
  82. GC12771 Etazolate hydrochloride PDE-4 inhibitor and selective GABA-A receptor modulator Etazolate hydrochloride Chemical Structure
  83. GC65173 FCPR03 FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively. FCPR03 Chemical Structure
  84. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  85. GC62977 FR-229934 FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1. FR-229934 Chemical Structure
  86. GN10231 Fraxin

    Fraxetol 8-glucoside, Fraxoside

     Fraxin Chemical Structure
  87. GC43715 Furamidine (hydrochloride) Furamidine (hydrochloride) (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine (hydrochloride) Chemical Structure
  88. GC15189 Gisadenafil besylate

    UK 369003

     PDE5 inhibitor Gisadenafil besylate Chemical Structure
  89. GC41486 Glaucine

    Boldine Dimethyl Ether, (+)-Glaucine, NSC 34396, 1,2,9,10-Tetramethoxyaporphine

     Glaucine is an alkaloid originally isolated from G. Glaucine Chemical Structure
  90. GC19168 GLPG1690

    Ziritaxestat

     GLPG1690(Ziritaxestat) is a novel autotaxin (ATX) inhibitor with an IC50 of 131 nM and a Ki of 15 nM. It effectively halts the progression of idiopathic pulmonary fibrosis. GLPG1690 Chemical Structure
  91. GC36187 GSK 256066 Trifluoroacetate GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK 256066 Trifluoroacetate Chemical Structure
  92. GC14180 GSK256066 A potent PDE4 inhibitor GSK256066 Chemical Structure
  93. GC14697 HA 130 autotaxin inhibitor HA 130 Chemical Structure
  94. GC10869 HA-155

    Autotaxin Inhibitor IV

     HA-155 is a potent autotaxin (ATX) type I inhibitor. HA-155 Chemical Structure
  95. GC64012 Hcyb1 Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 Chemical Structure
  96. GC11730 IBMX

    Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine, NSC 165960, SC-2964

     IBMX is a non-specific inhibitor of phosphodiesterase (PDE) inhibitor that inhibits PDE3, PDE4 and PDE5 with IC50 values of 6.5, 26.3 and 31.7 µm, except PDE8A, PDE8B and PDE9. IBMX Chemical Structure
  97. GC13275 Ibudilast

    AV 411,KC-404

     inhibitor of PDE4 Ibudilast Chemical Structure
  98. GN10278 Icariin

    Icariin is a flavonol glycoside.

     Icariin Chemical Structure
  99. GC32643 ICI 153110 ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. ICI 153110 Chemical Structure
  100. GC11313 ICI 63197 PDE4 inhibitor ICI 63197 Chemical Structure
  101. GC60199 Ilexsaponin B2 Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. Ilexsaponin B2 Chemical Structure

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