Lactate Dehydrogenase
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Lactate Dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate.
Mammalian lactate dehydrogenase (LDH) comprises three major families of conserved enzymes that catalyse the reversible interconversion of pyruvate and lactate, a key metabolic step in glycolysis and other metabolic pathways. At least five LDH tetrameric isozymes are reported in somatic mammalian tissues, comprising LDHA and LDHB subunits, whereas LDHC4 is found only in mature testis and spermatozoa, where it is required for male fertility. Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. At high concentrations of lactate, the enzyme exhibits feedback inhibition, and the rate of conversion of pyruvate to lactate is decreased. Dihydroorotate dehydrogenase (DHODH) is a key enzyme that catalyzes the oxidation of dihydroorotate (DHO) to produce orotate, a key step in pyrimidine biosynthesis.
Products Related to Lactate Dehydrogenase(22)
- GC13464GSK 2837808ACAS: 1445879-21-9Purity: >99.00%
GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC 50 of 2.6 nM and 43 nM for hLDHA and hLDHB.
- GC18183NifurtimoxCAS: 23256-30-6Purity: >98.00%
Nifurtimox is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T.
- GC19012(R)-GNE-140CAS: 2003234-63-5Purity: >99.00%
(R)-GNE-140 is an orally active lactate dehydrogenase A (LDHA) inhibitor. (R)-GNE-140 exhibits inhibitory activity against both LDHA (IC 50 =3nM) and LDHB (IC 50 =5nM), with its (R)-isomer demonstrating higher activity compared to the S-isomer.
- GC32694GNE-140 racemateCAS: 1802977-61-2Purity: >98.00%
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor.
- GC32993(S)-GNE-140CAS: 2003234-64-6Purity: >99.00%
(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).
- GC33468Rehmannioside ACAS: 81720-05-0Purity: >98.00%
Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.
- GC34011FX-11 (LDHA Inhibitor FX11)CAS: 213971-34-7Purity: >97.00%
FX-11 (LDHA Inhibitor FX11) was found to be a potent, competitive inhibitor of the human LDH-A's NADH binding pocket.
- GC351063-Dehydrotrametenolic acidCAS: 29220-16-4Purity: >98.00%
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity.
- GC38463ASLAN003CAS: 1035688-66-4Purity: >99.50%
ASLAN003 (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.
- GC38604Glomeratose ACAS: 202471-84-9Purity: >99.50%
Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia.
- GC39279hDHODH-IN-1CAS: 1173715-42-8Purity: >99.50%
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor.
- GC68710AXKO-0046 dihydrochloridePurity: >99.00%
AXKO-0046 dihydrochloride, an indole derivative, is a selective inhibitor of LDHB. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. It can be used for research on cancer metabolism.
- GC70681Nedosiran sodiumCAS: 2247026-22-6
Nedosiran sodium is a GalNAc-dsRNA conjugate designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme.
- GC81395ddhCTP trisodium solution (100 mM ± 3 mM)Purity: >98.00%
ddhCTP trisodium solution (100 mM ± 3 mM) is an endogenously produced pyrimidine base analog with a K d of 17.0 nM for LLDH and an IC 50 of 55.8 μM for GAPDH.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC13464 | GSK 2837808A | 1445879-21-9 | >99.00% | |
GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC 50 of 2.6 nM and 43 nM for hLDHA and hLDHB. | ||||
| GC14851 | Vidofludimus | 717824-30-1 | >98.50% | |
DHODH inhibitor | ||||
| GC18183 | Nifurtimox | 23256-30-6 | >98.00% | |
Nifurtimox is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. | ||||
| GC19012 | (R)-GNE-140 | 2003234-63-5 | >99.00% | |
(R)-GNE-140 is an orally active lactate dehydrogenase A (LDHA) inhibitor. (R)-GNE-140 exhibits inhibitory activity against both LDHA (IC 50 =3nM) and LDHB (IC 50 =5nM), with its (R)-isomer demonstrating higher activity compared to the S-isomer. | ||||
| GC32694 | GNE-140 racemate | 1802977-61-2 | >98.00% | |
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor. | ||||
| GC32838 | BAY-2402234 | 2225819-06-5 | >99.00% | |
A DHODH inhibitor | ||||
| GC32931 | LDH-IN-1 | 1964515-43-2 | >99.50% | |
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. | ||||
| GC32993 | (S)-GNE-140 | 2003234-64-6 | >99.00% | |
(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA). | ||||
| GC33468 | Rehmannioside A | 81720-05-0 | >98.00% | |
Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively. | ||||
| GC34011 | FX-11 (LDHA Inhibitor FX11) | 213971-34-7 | >97.00% | |
FX-11 (LDHA Inhibitor FX11) was found to be a potent, competitive inhibitor of the human LDH-A's NADH binding pocket. | ||||
| GC35106 | 3-Dehydrotrametenolic acid | 29220-16-4 | >98.00% | |
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity. | ||||
| GC38463 | ASLAN003 | 1035688-66-4 | >99.50% | |
ASLAN003 (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice. | ||||
| GC38604 | Glomeratose A | 202471-84-9 | >99.50% | |
Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia. | ||||
| GC39279 | hDHODH-IN-1 | 1173715-42-8 | >99.50% | |
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. | ||||
| GC39392 | Isomalt | 64519-82-0 | >98.00% | |
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. | ||||
| GC50151 | NHI 2 | 1269802-97-2 | >98% | |
LDHA inhibitor | ||||
| GC63795 | LDHA-IN-3 | 227010-33-5 | >99.50% | |
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer. | ||||
| GC68710 | AXKO-0046 dihydrochloride | - | >99.00% | |
AXKO-0046 dihydrochloride, an indole derivative, is a selective inhibitor of LDHB. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. It can be used for research on cancer metabolism. | ||||
| GC70681 | Nedosiran sodium | 2247026-22-6 | - | |
Nedosiran sodium is a GalNAc-dsRNA conjugate designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme. | ||||
| GC73684 | CHK-336 | 2743436-86-2 | >98.00% | |
CHK-336 (Example 1) is an orally active LDHA inhibitor (IC50<1 nM) that inhibits lactate production in mouse hepatocytes. | ||||
| GC79680 | GNE-140 | 1809794-70-4 | >98.00% | |
GNE-140 (Compound 28) is an external racemic mixture of (R)-GNE-140 and (S)-GNE-140. | ||||
| GC81395 | ddhCTP trisodium solution (100 mM ± 3 mM) | - | >98.00% | |
ddhCTP trisodium solution (100 mM ± 3 mM) is an endogenously produced pyrimidine base analog with a K d of 17.0 nM for LLDH and an IC 50 of 55.8 μM for GAPDH. | ||||