LIM Kinase (LIMK)

LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

Products Related to LIM Kinase (LIMK)(12)

GC15511 LIMKi 3
CAS: 1338247-35-0
Purity: >99.00%
LIMKi 3 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
GC16355 T 5601640
CAS: 924473-59-6
Purity: >98.50%
T 5601640 is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
GC19076 BMS-3
CAS: 1338247-30-5
Purity: >99.00%
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
GC38860 TH-257
CAS: 2244678-29-1
Purity: >98.50%
An inhibitor of LIMK1 and LIMK2
GC44094 LX7101 (hydrochloride)
CAS: 2319882-48-7
Purity: >98.00%
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.
GC50219 SR 7826
CAS: 1219728-20-7
Purity: >98%
Potent and selective LIMK inhibitor; antitumor
GC50404 CRT 0105950
CAS: 1661845-86-8
Purity: >98%
Potent LIMK1/2 inhibitor
GC62675 SM1-71
CAS: 2088179-99-9
Purity: >98%
SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines.
GC65207 R-10015
CAS: 2097938-51-5
Purity: >99.00%
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
GC68913 Curcolonol
CAS: 217817-09-9
Purity: >98%
Curcolonol is a furanoid sesquiterpene that can be isolated from several herbs. It has inhibitory activity against LIM kinase 1 and can be used in breast cancer research.
GC71011 DB0614
CAS: 2769753-47-9
Purity: >98.00%
DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases.
GC73353 TH470
CAS: 2834739-51-2
Purity: >99.00%
TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC15511	LIMKi 3	1338247-35-0	>99.00%
GC15511	LIMKi 3 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
GC16355	T 5601640	924473-59-6	>98.50%
GC16355	T 5601640 is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
GC19076	BMS-3	1338247-30-5	>99.00%
GC19076	BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
GC38860	TH-257	2244678-29-1	>98.50%
GC38860	An inhibitor of LIMK1 and LIMK2
GC44094	LX7101 (hydrochloride)	2319882-48-7	>98.00%
GC44094	LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.
GC50219	SR 7826	1219728-20-7	>98%
GC50219	Potent and selective LIMK inhibitor; antitumor
GC50404	CRT 0105950	1661845-86-8	>98%
GC50404	Potent LIMK1/2 inhibitor
GC62675	SM1-71	2088179-99-9	>98%
GC62675	SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines.
GC65207	R-10015	2097938-51-5	>99.00%
GC65207	R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
GC68913	Curcolonol	217817-09-9	>98%
GC68913	Curcolonol is a furanoid sesquiterpene that can be isolated from several herbs. It has inhibitory activity against LIM kinase 1 and can be used in breast cancer research.
GC71011	DB0614	2769753-47-9	>98.00%
GC71011	DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases.
GC73353	TH470	2834739-51-2	>99.00%
GC73353	TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research.