DNA Damage/DNA Repair
- MTH1(4)
- PARP(54)
- ATM/ATR(24)
- DNA Alkylating(16)
- DNA Ligases(3)
- DNA Methyltransferase(16)
- DNA-PK(22)
- HDAC(96)
- Nucleoside Antimetabolite/Analogue(124)
- Telomerase(10)
- Topoisomerase(114)
- tankyrase(5)
- Antifolate(25)
- CDK(203)
- Checkpoint Kinase (Chk)(27)
- CRISPR/Cas9(8)
- Deubiquitinase(43)
- DNA Alkylator/Crosslinker(58)
- DNA/RNA Synthesis(360)
- Eukaryotic Initiation Factor (eIF)(16)
- IRE1(22)
- LIM Kinase (LIMK)(8)
- TOPK(5)
- Casein Kinase(37)
- DNA Intercalating Agents(6)
- DNA/RNA Oxidative Damage(11)
- Cat.No. Product Name Information
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GC26084
XL413 (BMS-863233)
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
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GC25996
THZ1 2HCl
THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
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GC25594
LY3405105
LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity.
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GC25593
LY3143921 hydrate
LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.
-
GC25552
KT-531
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
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GC25372
Elimusertib (BAY-1895344) hydrochloride
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
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GC25139
Biphenyl-4-sulfonyl chloride
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
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GC68474
Pivanex
-
GC68455
CP681301
-
GC68448
AOH1160
-
GC68436
L82-G17
-
GC68332
4-Hydroperoxy Cyclophosphamide-d4
-
GC68161
5-AIQ
-
GC68035
PARP10/15-IN-1
-
GC68010
HDAC3-IN-T247
-
GC68006
PARP1-IN-11
-
GC67990
RPR121056
-
GC67984
Alteminostat
-
GC67970
DD-03-156
-
GC67963
USP15-IN-1
-
GC67962
Simmiparib
-
GC67960
AVG-233
-
GC67946
Adenine-d1
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GC67915
FT3967385
-
GC67906
OM-153
-
GC67886
DC-U4106
-
GC67876
APE1-IN-1
-
GC67865
RP-6685
-
GC67785
L82
-
GC67775
Casein kinase 1δ-IN-3
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GC67716
Mitonafide
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GC67712
STAMBP-IN-1
-
GC67674
CRA-026440 hydrochloride
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GC67671
5-Methylcytidine 5′-triphosphate trisodium
-
GC52516
Erbstatin
A tyrosine kinase inhibitor
-
GC52513
Indolimine-214
A genotoxic gut microbiota metabolite
-
GC52455
Pixantrone-d8 (maleate)
An internal standard for the quantification of pixantrone
-
GC52391
306-O12B-3
An ionizable cationic lipidoid
-
GC52351
Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide
A biotinylated and citrullinated α-enolase peptide
-
GC52303
Ethyl Mycophenolate
A potential impurity found in commercial preparations of mycophenolate mofetil
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GC67477
Tiazofurin
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities.
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GC67384
2′-Deoxy-β-L-uridine
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.
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GC66885
Bz-rC Phosphoramidite
Bz-rC Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
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GC66713
2'-O-MOE-5-Me-C(Bz)
2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates.
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GC66711
DMTr-LNA-5MeU-3-CED-phosphoramidite
DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
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GC66659
LNA-A(Bz) amidite
LNA-A(Bz) amidite can be used for synthesis of ASOs (antisense oligonucleotides).
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GC66658
5-Me-dC(Ac) amidite
5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA.
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GC66657
2'-O-MOE-5-Me-rC
2'-O-MOE-5-Me-rC is an active compound. 2'-O-MOE-5-Me-rC can be used for oligonucleotide synthesis.
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GC66656
2'-O-MOE-rC
2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA.
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GC66655
2'-O,4'-C-Methyleneguanosine
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand.
-
GC66654
2'-O,4'-C-Methylenecytidine
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.
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GC66652
2'-O-MOE-U
2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis.
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GC66651
2'-O,4'-C-Methyleneadenosine
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.
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GC66622
L-Guanosine
L-Guanosine is the L-configuration of Guanosine . Guanosine is a purine nucleoside with anti-herpesvirus activity.
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GC66475
CDK9-IN-10
CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811).
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GC66446
LDC4297 hydrochloride
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection.
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GC66438
USP5-IN-1
USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate.
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GC66430
Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
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GC66422
Trimethoprim-d9
Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.
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GC66387
Lometrexol disodium
Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
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GC66325
N2-Acetylguanine
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent.
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GC66210
DMT-2'O-MOE-rG(ib) Phosphoramidite
DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides.
-
GC66091
2'-O-MOE-5-Me-rU
2'-O-MOE-5-Me-rU is an active compound. 2'-O-MOE-5-Me-rU can be used for oligonucleotide synthesis.
-
GC66075
N1-Methylpseudouridine-5′-triphosphate trisodium
N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
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GC66060
7-Iodo-2',3'-dideoxy-7-deaza-guanosine
7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.
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GC66058
7-TFA-ap-7-Deaza-dA
7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
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GC66055
5-Phenylpentan-2-one
5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research.
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GC66052
HDAC-IN-40
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects.
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GC66033
Casein kinase 1δ-IN-1
Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research.
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GC66009
CDK5-IN-3
CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
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GC65997
(S)-LY3177833 hydrate
(S)-LY3177833 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor. (S)-LY3177833 hydrate shows broad in vitro anticancer activity.
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GC65965
MPT0E028
MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity.
-
GC65939
Indimitecan
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.
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GC65927
PARP-2-IN-1
PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM.
-
GC65907
KSQ-4279
KSQ-4279 (USP1-IN-1, Formula I) is a USP1 and PARP inhibitor (extracted from patent WO2021163530).
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GC65899
AZ3391
AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23).
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GC65891
PCLX-001
PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research.
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GC65878
Cimpuciclib tosylate
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
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GC65877
(S)-GFB-12811
(S)-GFB-12811 (compound 596) is a potent and selective CDK5 inhibitor, with an IC50 value less than 10 nM. (S)-GFB-12811 can be used in the research of cell cycle progression, neuronal development, tumorigenesis.
-
GC65675
7-Iodo-7-deaza-2'-deoxyguanosine
7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a deoxyguanosine derivative that can be used in DNA synthesis and sequencing reactions.
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GC65617
DHFR-IN-3
DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively.
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GC52183
2'-O-Methyl-5-methyluridine
-
GC52175
IQA
-
GC52171
Clindamycin-d3 (hydrochloride)
Clindamycin-d3 (hydrochloride) is the deuterium labeled Clindamycin.
-
GC52165
Minosaminomycin
-
GC52129
3-Amino-5-hydroxybenzoic Acid
-
GC65577
JH-XVI-178
JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.
-
GC65562
5'-O-DMT-N6-Me-2'-dA
5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.
-
GC65561
N6-Methyl-dA phosphoramidite
N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.
-
GC65551
1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine
1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
-
GC65546
DNMT3A-IN-1
DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor.
-
GC65540
eIF4A3-IN-2
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.
-
GC65525
7-TFA-ap-7-Deaza-dG
5'-O-TBDMS-dG is a modified nucleoside.
-
GC65520
5'-DMT-3'-TBDMS-ibu-rG
5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside.
-
GC65514
ATR inhibitor 1
ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ.
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GC65489
2'-F-Bz-dC Phosphoramidite
2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides.
-
GC65482
5'-O-DMT-N6-ibu-dA
5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides.
-
GC65471
JH-XI-10-02
JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.
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GC65462
Adenosine 5′-monophosphoramidate sodium
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis.
-
GC65460
HDACs/mTOR Inhibitor 1
HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo.