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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC68474 Pivanex Pivanex Chemical Structure
  3. GC68455 CP681301 CP681301 Chemical Structure
  4. GC68448 AOH1160 AOH1160 Chemical Structure
  5. GC68436 L82-G17 L82-G17 Chemical Structure
  6. GC68332 4-Hydroperoxy Cyclophosphamide-d4 4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure
  7. GC68161 5-AIQ 5-AIQ Chemical Structure
  8. GC68035 PARP10/15-IN-1 PARP10/15-IN-1 Chemical Structure
  9. GC68010 HDAC3-IN-T247 HDAC3-IN-T247 Chemical Structure
  10. GC68006 PARP1-IN-11 PARP1-IN-11 Chemical Structure
  11. GC67990 RPR121056 RPR121056 Chemical Structure
  12. GC67984 Alteminostat Alteminostat Chemical Structure
  13. GC67970 DD-03-156 DD-03-156 Chemical Structure
  14. GC67963 USP15-IN-1 USP15-IN-1 Chemical Structure
  15. GC67962 Simmiparib Simmiparib Chemical Structure
  16. GC67960 AVG-233 AVG-233 Chemical Structure
  17. GC67946 Adenine-d1 Adenine-d1 Chemical Structure
  18. GC67915 FT3967385 FT3967385 Chemical Structure
  19. GC67906 OM-153 OM-153 Chemical Structure
  20. GC67886 DC-U4106 DC-U4106 Chemical Structure
  21. GC67876 APE1-IN-1 APE1-IN-1 Chemical Structure
  22. GC67865 RP-6685 RP-6685 Chemical Structure
  23. GC67785 L82 L82 Chemical Structure
  24. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3 Chemical Structure
  25. GC67716 Mitonafide Mitonafide Chemical Structure
  26. GC67712 STAMBP-IN-1 STAMBP-IN-1 Chemical Structure
  27. GC67674 CRA-026440 hydrochloride CRA-026440 hydrochloride Chemical Structure
  28. GC67671 5-Methylcytidine 5′-triphosphate trisodium 5-Methylcytidine 5′-triphosphate trisodium Chemical Structure
  29. GC52516 Erbstatin A tyrosine kinase inhibitor Erbstatin Chemical Structure
  30. GC52513 Indolimine-214 A genotoxic gut microbiota metabolite Indolimine-214 Chemical Structure
  31. GC52455 Pixantrone-d8 (maleate) An internal standard for the quantification of pixantrone Pixantrone-d8 (maleate) Chemical Structure
  32. GC52391 306-O12B-3 An ionizable cationic lipidoid 306-O12B-3 Chemical Structure
  33. GC52351 Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide A biotinylated and citrullinated α-enolase peptide Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide Chemical Structure
  34. GC52303 Ethyl Mycophenolate A potential impurity found in commercial preparations of mycophenolate mofetil Ethyl Mycophenolate Chemical Structure
  35. GC67477 Tiazofurin Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin Chemical Structure
  36. GC67384 2′-Deoxy-β-L-uridine 2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase. 2′-Deoxy-β-L-uridine Chemical Structure
  37. GC66885 Bz-rC Phosphoramidite Bz-rC Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides. Bz-rC Phosphoramidite Chemical Structure
  38. GC66713 2'-O-MOE-5-Me-C(Bz) 2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates. 2'-O-MOE-5-Me-C(Bz) Chemical Structure
  39. GC66711 DMTr-LNA-5MeU-3-CED-phosphoramidite DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative. DMTr-LNA-5MeU-3-CED-phosphoramidite Chemical Structure
  40. GC66659 LNA-A(Bz) amidite LNA-A(Bz) amidite can be used for synthesis of ASOs (antisense oligonucleotides). LNA-A(Bz) amidite Chemical Structure
  41. GC66658 5-Me-dC(Ac) amidite 5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA. 5-Me-dC(Ac) amidite Chemical Structure
  42. GC66657 2'-O-MOE-5-Me-rC 2'-O-MOE-5-Me-rC is an active compound. 2'-O-MOE-5-Me-rC can be used for oligonucleotide synthesis. 2'-O-MOE-5-Me-rC Chemical Structure
  43. GC66656 2'-O-MOE-rC 2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA. 2'-O-MOE-rC Chemical Structure
  44. GC66655 2'-O,4'-C-Methyleneguanosine 2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand. 2'-O,4'-C-Methyleneguanosine Chemical Structure
  45. GC66654 2'-O,4'-C-Methylenecytidine 2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands. 2'-O,4'-C-Methylenecytidine Chemical Structure
  46. GC66652 2'-O-MOE-U 2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis. 2'-O-MOE-U Chemical Structure
  47. GC66651 2'-O,4'-C-Methyleneadenosine 2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog. 2'-O,4'-C-Methyleneadenosine Chemical Structure
  48. GC66622 L-Guanosine L-Guanosine is the L-configuration of Guanosine . Guanosine is a purine nucleoside with anti-herpesvirus activity. L-Guanosine Chemical Structure
  49. GC66475 CDK9-IN-10 CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811). CDK9-IN-10 Chemical Structure
  50. GC66446 LDC4297 hydrochloride LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection. LDC4297 hydrochloride Chemical Structure
  51. GC66438 USP5-IN-1 USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate. USP5-IN-1 Chemical Structure
  52. GC66430 Fludarabine triphosphate trisodium Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis. Fludarabine triphosphate trisodium Chemical Structure
  53. GC66422 Trimethoprim-d9 Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment. Trimethoprim-d9 Chemical Structure
  54. GC66387 Lometrexol disodium Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. Lometrexol disodium Chemical Structure
  55. GC66325 N2-Acetylguanine N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent. N2-Acetylguanine Chemical Structure
  56. GC66210 DMT-2'O-MOE-rG(ib) Phosphoramidite DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides. DMT-2'O-MOE-rG(ib) Phosphoramidite Chemical Structure
  57. GC66091 2'-O-MOE-5-Me-rU 2'-O-MOE-5-Me-rU is an active compound. 2'-O-MOE-5-Me-rU can be used for oligonucleotide synthesis. 2'-O-MOE-5-Me-rU Chemical Structure
  58. GC66075 N1-Methylpseudouridine-5′-triphosphate trisodium N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability. N1-Methylpseudouridine-5′-triphosphate trisodium Chemical Structure
  59. GC66060 7-Iodo-2',3'-dideoxy-7-deaza-guanosine 7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions. 7-Iodo-2',3'-dideoxy-7-deaza-guanosine Chemical Structure
  60. GC66058 7-TFA-ap-7-Deaza-dA 7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid. 7-TFA-ap-7-Deaza-dA Chemical Structure
  61. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  62. GC66052 HDAC-IN-40 HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects. HDAC-IN-40 Chemical Structure
  63. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1 Chemical Structure
  64. GC66009 CDK5-IN-3 CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). CDK5-IN-3 Chemical Structure
  65. GC65997 (S)-LY3177833 hydrate (S)-LY3177833 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor. (S)-LY3177833 hydrate shows broad in vitro anticancer activity. (S)-LY3177833 hydrate Chemical Structure
  66. GC65965 MPT0E028 MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity. MPT0E028 Chemical Structure
  67. GC65939 Indimitecan Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. Indimitecan Chemical Structure
  68. GC65927 PARP-2-IN-1 PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. PARP-2-IN-1 Chemical Structure
  69. GC65907 KSQ-4279 KSQ-4279 (USP1-IN-1, Formula I) is a USP1 and PARP inhibitor (extracted from patent WO2021163530). KSQ-4279 Chemical Structure
  70. GC65899 AZ3391 AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23). AZ3391 Chemical Structure
  71. GC65891 PCLX-001 PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research. PCLX-001 Chemical Structure
  72. GC65878 Cimpuciclib tosylate Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity. Cimpuciclib tosylate Chemical Structure
  73. GC65877 (S)-GFB-12811 (S)-GFB-12811 (compound 596) is a potent and selective CDK5 inhibitor, with an IC50 value less than 10 nM. (S)-GFB-12811 can be used in the research of cell cycle progression, neuronal development, tumorigenesis. (S)-GFB-12811 Chemical Structure
  74. GC65675 7-Iodo-7-deaza-2'-deoxyguanosine 7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a deoxyguanosine derivative that can be used in DNA synthesis and sequencing reactions. 7-Iodo-7-deaza-2'-deoxyguanosine Chemical Structure
  75. GC65617 DHFR-IN-3 DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively. DHFR-IN-3 Chemical Structure
  76. GC52183 2'-O-Methyl-5-methyluridine 2'-O-Methyl-5-methyluridine Chemical Structure
  77. GC52175 IQA IQA Chemical Structure
  78. GC52171 Clindamycin-d3 (hydrochloride) Clindamycin-d3 (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin-d3 (hydrochloride) Chemical Structure
  79. GC52165 Minosaminomycin Minosaminomycin Chemical Structure
  80. GC52129 3-Amino-5-hydroxybenzoic Acid 3-Amino-5-hydroxybenzoic Acid Chemical Structure
  81. GC65577 JH-XVI-178 JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties. JH-XVI-178 Chemical Structure
  82. GC65562 5'-O-DMT-N6-Me-2'-dA 5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects. 5'-O-DMT-N6-Me-2'-dA Chemical Structure
  83. GC65561 N6-Methyl-dA phosphoramidite N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides. N6-Methyl-dA phosphoramidite Chemical Structure
  84. GC65551 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside. 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine Chemical Structure
  85. GC65546 DNMT3A-IN-1 DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor. DNMT3A-IN-1 Chemical Structure
  86. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2 Chemical Structure
  87. GC65525 7-TFA-ap-7-Deaza-dG 5'-O-TBDMS-dG is a modified nucleoside. 7-TFA-ap-7-Deaza-dG Chemical Structure
  88. GC65520 5'-DMT-3'-TBDMS-ibu-rG 5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside. 5'-DMT-3'-TBDMS-ibu-rG Chemical Structure
  89. GC65514 ATR inhibitor 1 ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1 Chemical Structure
  90. GC65489 2'-F-Bz-dC Phosphoramidite 2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides. 2'-F-Bz-dC Phosphoramidite Chemical Structure
  91. GC65482 5'-O-DMT-N6-ibu-dA 5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides. 5'-O-DMT-N6-ibu-dA Chemical Structure
  92. GC65471 JH-XI-10-02 JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 Chemical Structure
  93. GC65462 Adenosine 5′-monophosphoramidate sodium Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate sodium Chemical Structure
  94. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  95. GC65440 ddCTP trisodium ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium Chemical Structure
  96. GC65435 Monalizumab Monalizumab Chemical Structure
  97. GC65434 CDK7/12-IN-1 CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively. CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth. CDK7/12-IN-1 Chemical Structure
  98. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  99. GC65408 7-Deaza-2'-deoxy-7-iodoadenosine 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine. 7-Deaza-2'-deoxy-7-iodoadenosine Chemical Structure
  100. GC65402 5'-O-DMT-2'-O-TBDMS-Bz-rC 5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA. 5'-O-DMT-2'-O-TBDMS-Bz-rC Chemical Structure
  101. GC65401 5'-O-TBDMS-dU 5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides. 5'-O-TBDMS-dU Chemical Structure

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