LRRK2

LRRK2 inhibitor

A selective LRRK2 inhibitor

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.

IKK-16 (hydrochloride) is a novel, orally active selective inhibitor of IκB kinase (IKK), with IC₅₀ values of 40nM, 70nM, and 200nM against IKK-2, IKK complex, and IKK-1.

LRRK2 inhibitor

CZC 54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively.

LRRK2 inhibitor

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.

MLi-2 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), with an IC₅₀ value of 0.76nM. MLi-2 exhibits excellent central nervous system penetration and serves as an important tool compound for studying LRRK2 function and the pathological mechanisms of Parkinson’s disease (PD).

CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively.

GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.

PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo.

PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively.

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively.

EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM).

LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8.

LRRK2-IN-7 is an effective, selective, CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. The selectivity of LRRK2-IN-7 is over 1000-fold for other kinases, ion channels and CYP enzymes.

XL01126 is a potent LRRK2 PROTAC (DC50: 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2)) composed of the VHL ligand VH 101, thiol and the LRRK2 inhibitor HG-10-102-01.

JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader.

CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC50 of 9 nM.

LRRK2-IN-9 (compound 78) is a LRRK2 inhibitor that can be used in studies related to Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis [1] .

LRRK2 inhibitor, brain-penetrant, potent and selective

Potent and selective LRRK2 inhibitor

Potent and selective LRRK2 inhibitor