MALT1
Read More about this categoryShow Less
MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.
Products Related to MALT1(11)
- GC45192Z-VRPR-FMK (trifluoroacetate salt)Purity: >90.00%
Z-VRPR-FMK is a selective, irreversible inhibitor of the paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an endopeptidase that targets BCL10 and reduces NF-κB activation in lymphocytes at 12.5 to 75 μM.
- GC61041Mepazine hydrochlorideCAS: 2975-36-2Purity: >98.00%
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
- GC62115JNJ-67856633CAS: 2230273-76-2Purity: >99.50%
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. JNJ-67856633 in some cases lead to tumor stasis.
- GC81039PROTAC MALT1 Degrader-1CAS: 2975664-37-8Purity: >98.00%
PROTAC MALT1 Degrader-1 (Compound 176) is a MALT1 PROTAC degrader.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC36534 | MALT1 inhibitor MI-2 | 1047953-91-2 | >99.50% | |
A MALT1 inhibitor | ||||
| GC45192 | Z-VRPR-FMK (trifluoroacetate salt) | - | >90.00% | |
Z-VRPR-FMK is a selective, irreversible inhibitor of the paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an endopeptidase that targets BCL10 and reduces NF-κB activation in lymphocytes at 12.5 to 75 μM. | ||||
| GC61041 | Mepazine hydrochloride | 2975-36-2 | >98.00% | |
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis. | ||||
| GC62115 | JNJ-67856633 | 2230273-76-2 | >99.50% | |
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. JNJ-67856633 in some cases lead to tumor stasis. | ||||
| GC62464 | MLT-943 | 1832576-04-1 | >99.50% | |
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. | ||||
| GC62611 | MLT-231 | 2682102-10-7 | >99.50% | |
MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse. | ||||
| GC65301 | MLT-748 | 1832578-30-9 | >99.00% | |
MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. | ||||
| GC65505 | MLT-985 | 1832576-25-6 | >98% | |
MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC50 value of 3 nM. | ||||
| GC67992 | MLT-747 | 2097853-86-4 | >98% | |
| GC68218 | Mepazine | 60-89-9 | >98% | |
| GC81039 | PROTAC MALT1 Degrader-1 | 2975664-37-8 | >98.00% | |
PROTAC MALT1 Degrader-1 (Compound 176) is a MALT1 PROTAC degrader. | ||||